Technology Process of (S)-7-cyano-4-(3-fluoro-2-methoxybenzyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-2-ylcarbamic acid isopropyl ester
There total 11 articles about (S)-7-cyano-4-(3-fluoro-2-methoxybenzyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-2-ylcarbamic acid isopropyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium carbonate / methanol; water / 20 °C
2.1: acetic acid / 5 h / Reflux
3.1: hydrazine hydrate / tetrahydrofuran; water / 22 h / 20 - 55 °C
4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 20 °C
5.1: Chiralcel OJ 8 / Resolution of racemate
6.1: zinc diacetate; zinc / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C
7.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
7.2: 4 h / 20 °C
8.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
hydrogenchloride; zinc diacetate; sodium hydrogencarbonate; sodium carbonate; caesium carbonate; hydrazine hydrate; acetic acid; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Chiralcel OJ 8 / Resolution of racemate
2.1: zinc diacetate; zinc / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C
3.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
3.2: 4 h / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
With
hydrogenchloride; zinc diacetate; caesium carbonate; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; N,N-dimethyl-formamide;
