Technology Process of N-(2,4-difluoro-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide
There total 5 articles about N-(2,4-difluoro-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)ureido)phenyl)propane-1-sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dimethyl sulfoxide;
at 60 - 115 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanol / 2 h / Cold water bath
2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
3.1: triethylamine / dichloromethane / 1 h / 20 °C / Cool water bath
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 4 h / 20 °C / Reflux
5.2: 1 h / Reflux
6.1: triethylamine / dimethyl sulfoxide / 60 - 115 °C
With
diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere
2.1: triethylamine / dichloromethane / 1 h / 20 °C / Cool water bath
3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 4 h / 20 °C / Reflux
4.2: 1 h / Reflux
5.1: triethylamine / dimethyl sulfoxide / 60 - 115 °C
With
diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide;