2-(2-METHYL-BENZOYL)-BENZOIC ACIDMETHYL ESTER

Base Information

• Chemical Name: 2-(2-METHYL-BENZOYL)-BENZOIC ACIDMETHYL ESTER
• CAS No.: 21147-26-2
• Molecular Formula: C16H14 O3
• Molecular Weight: 254.285
• Hs Code.: 2918300090
• Mol file: 21147-26-2.mol

Synonyms:Benzoicacid, o-(o-toluoyl)-, methyl ester (8CI)

Chemical Property of 2-(2-METHYL-BENZOYL)-BENZOIC ACIDMETHYL ESTER

Chemical Property:

• PSA: 43.37000
• LogP: 3.01260
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

Methyl2-(2-methylbenzoyl)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-METHYL-BENZOYL)-BENZOIC ACIDMETHYL ESTER

There total 8 articles about 2-(2-METHYL-BENZOYL)-BENZOIC ACIDMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 2-(2-methylbenzoyl)benzoic acid methyl ester (21147-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; benzene

2: methanol; diethyl ether

With methanol; diethyl ether; benzene;

DOI:10.1021/ja01851a014

Reference yield:

phthalic anhydride (85-44-9) → 2-(2-methylbenzoyl)benzoic acid methyl ester (21147-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / benzene; diethyl ether / 1.5 h / Heating

2: H₂SO₄ / 52 h / Heating

With sulfuric acid; In diethyl ether; benzene;

DOI:10.1021/jo048055x

Reference yield:

ortho-tolylmagnesium bromide (932-31-0) → 2-(2-methylbenzoyl)benzoic acid methyl ester (21147-26-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / benzene; diethyl ether / 1.5 h / Heating

2: H₂SO₄ / 52 h / Heating

With sulfuric acid; In diethyl ether; benzene;

DOI:10.1021/jo048055x

upstream raw materials:

diazomethane

methylbenzoyl-benzoic acid

methanol

hydrogenchloride

Downstream raw materials:

(S)-3-(2-methylphenyl)isobenzofuran-1(3H)-one

2-(3-oxo-1,3-dihydroisobenzofuran-1-yl)benzoic acid methyl ester

3-(2-methylphenyl)isobenzofuran-1(3H)one

Refernces

• 1、 Lu, Bin,Zhao, Mengmeng,Ding, Guangni,Xie, Xiaomin,Jiang, Lili,Ratovelomanana-Vidal, Virginie,Zhang, Zhaoguo. "Ruthenium-Catalyzed Enantioselective Hydrogenation/Lactonization of 2-Acylarylcarboxylates: Direct Access to Chiral 3-Substituted Phthalides". . p. 3989 - 3996. Retrieved 2017/09/13.