3-(DIETHYLAMINO)PYRROLIDINE

Base Information

• Chemical Name: 3-(DIETHYLAMINO)PYRROLIDINE
• CAS No.: 20984-81-0
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Hs Code.: 2933990090
• Mol file: 20984-81-0.mol

Synonyms:Pyrrolidine,3-(diethylamino)- (8CI);3-Diethylaminopyrrolidine;Diethyl(pyrrolidin-3-yl)amine;N,N-Diethylpyrrolidin-3-amine;

Chemical Property of 3-(DIETHYLAMINO)PYRROLIDINE

Chemical Property:

• Refractive Index: 1.4680-1.4720
• Boiling Point: 199.298 °C at 760 mmHg
• Flash Point: 69.569 °C
• PSA: 15.27000
• Density: 0.905 g/cm³
• LogP: 1.01890

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Diethylpyrrolidin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(DIETHYLAMINO)PYRROLIDINE

There total 1 articles about 3-(DIETHYLAMINO)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ diethyl-pyrrolidin-3-yl-amine (20984-81-0,1181105-70-3)

Guidance literature:

1-Benzyl-3-diethylamino-pyrrolidin, H2 (Pd/C);

DOI:10.1021/jm00312a606

Reference yield: 82.0%

5-chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide (1035271-18-1) + diethyl-pyrrolidin-3-yl-amine (20984-81-0,1181105-70-3) → 5-(3-diethylaminopyrrolidin-1-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide (1035270-43-9)

Guidance literature:

In dimethyl sulfoxide; at 20 - 25 ℃; for 0.833333h;

Reference yield: 75.0%

5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid (1107658-88-7) + diethyl-pyrrolidin-3-yl-amine (20984-81-0,1181105-70-3) → [5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone (1107656-33-6)

Guidance literature:

5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazole-3-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 4h;

diethyl-pyrrolidin-3-yl-amine; With triethylamine; In N,N-dimethyl-formamide; for 2h;

Downstream raw materials:

5-(3-diethylaminopyrrolidin-1-yl)-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide

[5-(3-benzofuran-2-yl-phenyl)-2-methyl-2H-pyrazol-3-yl]-(3-diethylamino-pyrrolidin-1-yl)-methanone

(rac)-(3-diethylamino-pyrrolidin-1-yl)-[2-(3-hexyl-phenyl)-5-iodo-3-methyl-3H-imidazol-4-yl]-methanone

methyl 2-chloro-5-(3-(diethylamino)pyrrolidin-1-yl)benzoate

Refernces