2-amino-4-methoxy-5,6-diphenylpyrimidine

Base Information

• Chemical Name: 2-amino-4-methoxy-5,6-diphenylpyrimidine
• CAS No.: 282543-41-3
• Molecular Formula: C₁₇H₁₅N₃O
• Molecular Weight: 277.326
• Mol file: 282543-41-3.mol

Synonyms:2-amino-4-methoxy-5,6-diphenylpyrimidine

Chemical Property of 2-amino-4-methoxy-5,6-diphenylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-4-methoxy-5,6-diphenylpyrimidine

There total 3 articles about 2-amino-4-methoxy-5,6-diphenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-amino-5-bromo-4-methoxy-6-phenylpyrimidine (282543-39-9) + phenylboronic acid (98-80-6) → 2-amino-4-methoxy-5,6-diphenylpyrimidine (282543-41-3)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; for 18h; Heating;

DOI:10.1016/S0968-0896(00)00017-1

Reference yield:

bropirimine (56741-95-8) → 2-amino-4-methoxy-5,6-diphenylpyrimidine (282543-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / POCl₃ / 0.75 h / Heating

2: 93 percent / methanol / 0.5 h / Heating

3: 75 percent / Na₂CO₃ / Pd(PPh₃)4 / toluene; H₂O; ethanol / 18 h / Heating

With sodium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene; 1: Substitution / 2: Substitution / 3: Suzuki cross-coupling;

DOI:10.1016/S0968-0896(00)00017-1

Reference yield:

2-amino-5-bromo-4-chloro-6-phenylpyrimidine (106791-93-9) → 2-amino-4-methoxy-5,6-diphenylpyrimidine (282543-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / methanol / 0.5 h / Heating

2: 75 percent / Na₂CO₃ / Pd(PPh₃)4 / toluene; H₂O; ethanol / 18 h / Heating

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethanol; water; toluene; 1: Substitution / 2: Suzuki cross-coupling;

DOI:10.1016/S0968-0896(00)00017-1

upstream raw materials:

2-amino-5-bromo-4-methoxy-6-phenylpyrimidine

phenylboronic acid

bropirimine

2-amino-5-bromo-4-chloro-6-phenylpyrimidine

Downstream raw materials:

2-amino-5,6-diphenylpyrimidin-4(3H)-one

Refernces