3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one

Base Information

• Chemical Name: 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one
• CAS No.: 1413849-87-2
• Molecular Formula: C₁₉H₁₆O₂
• Molecular Weight: 276.335
• Mol file: 1413849-87-2.mol

Synonyms:3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one

Chemical Property of 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one

There total 6 articles about 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C19H14O2 → 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one (1413849-87-2)

Guidance literature:

With potassium carbonate; toluene-4-sulfonic acid hydrazide; In 1,4-dioxane; at 110 ℃; for 3h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2015.08.027

Reference yield: 62.0%

(±)-2-(1-naphthyl)-2H-chromene → 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one (1413849-87-2)

Guidance literature:

With chloroauric acid; water; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2012.08.117

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 3-(2-hydroxyphenyl)-1-(naphthalen-1-yl)propan-1-one (1413849-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethanol

2: sodium tetrahydroborate / isopropyl alcohol

3: chloroauric acid; water / dichloromethane / 24 h / 20 °C

With sodium tetrahydroborate; chloroauric acid; water; sodium hydroxide; In ethanol; dichloromethane; water; isopropyl alcohol; 1: |Claisen-Schmidt Condensation;

DOI:10.1016/j.tetlet.2012.08.117

upstream raw materials:

o-hydroxyacetophenone

1-(2-hydroxyphenyl)-3-(naphthalen-1-yl) prop-2-en-1-one

1'-naphthacetophenone

salicylaldehyde

Refernces

• 1、 Maiti, Gourhari,Kayal, Utpal,Karmakar, Rajiv,Bhattacharya, Rudraksha N.. "An unexpected rearrangement-hydration reaction sequence of 2H-chromenes to dihydrochalcones under catalysis of HAuCl4". . p. 6321 - 6325,5. Retrieved 2012/12/12.