Technology Process of ethyl 4-(benzylamino)bicyclo[2.2.2]oct-2-ene-1-carboxylate
There total 7 articles about ethyl 4-(benzylamino)bicyclo[2.2.2]oct-2-ene-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N-dimethyl acetamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide;
In
toluene;
at 120 ℃;
for 43h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / toluene / 7 h / Reflux; Dean-Stark conditions
1.2: 0.5 h / 20 °C
2.1: ethanol; sodium tetrahydroborate / 0.5 h / 0 - 20 °C
3.1: triethylamine / toluene; tetrahydrofuran / 1.5 h
4.1: sodium iodide; N,N-dimethyl acetamide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 43 h / 120 °C
With
sodium tetrahydroborate; ethanol; N,N-dimethyl acetamide; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide;
In
tetrahydrofuran; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethanol; sodium tetrahydroborate / 0.5 h / 0 - 20 °C
2: triethylamine / toluene; tetrahydrofuran / 1.5 h
3: sodium iodide; N,N-dimethyl acetamide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 43 h / 120 °C
With
sodium tetrahydroborate; ethanol; N,N-dimethyl acetamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide;
In
tetrahydrofuran; toluene;