(+)-norephedrine formate

Base Information

• Chemical Name: (+)-norephedrine formate
• CAS No.: 81626-19-9
• Molecular Formula: CH₂O₂*C₉H₁₃NO
• Molecular Weight: 197.234
• Mol file: 81626-19-9.mol

Synonyms:(+)-norephedrine formate

Chemical Property of (+)-norephedrine formate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (+)-norephedrine formate

There total 1 articles about (+)-norephedrine formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

u-2-amino-1-phenylpropan-1-ol (14838-15-4,58550-13-3,757124-50-8) + methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5) → (1RS,2SR)-2-amino-1-phenyl-propan-1-ol; formate (53325-64-7,53510-77-3,53630-90-3,68123-43-3,81626-19-9)

Guidance literature:

With ethanol; nickel; Hydrogenation;

DOI:10.1021/ja01314a054

Reference yield: 92.0%

(+)-norephedrine formate (81626-19-9) → (1S,2R)-2-formamido-1-phenylpropanol (81626-21-3)

Guidance literature:

In toluene; for 48h; Heating;

DOI:10.1021/jo00134a026

Reference yield:

(+)-norephedrine formate (81626-19-9) → (+)-(2R)-2-Amino-1-phenyl-1-propanone hydrochloride (76333-53-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / toluene / 48 h / Heating

2: 83 percent / CrO₃, pyridine / CH₂Cl₂ / 0.25 h

3: 72 percent / 20percent HCl / 5 h / 40 °C

With pyridine; chromium(VI) oxide; hydrogenchloride; In dichloromethane; toluene;

DOI:10.1021/jo00134a026

upstream raw materials:

u-2-amino-1-phenylpropan-1-ol

methylammonium carbonate

Downstream raw materials:

(1S,2R)-2-formamido-1-phenylpropanol

(+)-(2R)-2-Amino-1-phenyl-1-propanone hydrochloride

(+)-N-formyl-α-aminopropiophenone