Technology Process of 6-hydroxy-2-methyl-3-phenyl-1H-indole
There total 4 articles about 6-hydroxy-2-methyl-3-phenyl-1H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,10-Phenanthroline; carbon monoxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
N,N-dimethyl-formamide;
at 120 ℃;
for 72h;
under 4560.31 Torr;
DOI:10.1016/j.tet.2021.132331
- Guidance literature:
-
propiophenone N-tosylhydrazone; 4-bromo-3-nitrophenol;
With
bis-triphenylphosphine-palladium(II) chloride; lithium tert-butoxide;
In
1,4-dioxane;
at 100 ℃;
for 8h;
Inert atmosphere;
With
carbon monoxide; 1,3-bis-(diphenylphosphino)propane; N,N-dimethyl-formamide;
In
1,4-dioxane;
at 140 ℃;
for 72h;
under 4560.31 Torr;
Inert atmosphere;
DOI:10.1016/j.tet.2021.132331
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; lithium tert-butoxide / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere
1.2: 72 h / 140 °C / 4560.31 Torr / Inert atmosphere
2.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; 1,10-Phenanthroline; carbon monoxide / N,N-dimethyl-formamide / 72 h / 120 °C / 4560.31 Torr
With
bis-triphenylphosphine-palladium(II) chloride; 1,10-Phenanthroline; carbon monoxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; lithium tert-butoxide;
In
1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2021.132331
