5-chloro-2,4-difluoropyrimidine

Base Information

• Chemical Name: 5-chloro-2,4-difluoropyrimidine
• CAS No.: 25151-07-9
• Molecular Formula: C4H Cl F2 N2
• Molecular Weight: 150.515
• Hs Code.: 2933599090
• Mol file: 25151-07-9.mol

Synonyms:2,4-Difluoro-5-chloropyrimidine;5-Chloro-2,4-difluoropyrimidine

Chemical Property of 5-chloro-2,4-difluoropyrimidine

Chemical Property:

• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.479
• Boiling Point: 250.6°C at 760 mmHg
• PKA: -3.94±0.29(Predicted)
• Flash Point: 105.4°C
• PSA: 25.78000
• Density: 1.563g/cm³
• LogP: 1.40820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2,4-difluoropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-2,4-difluoropyrimidine is a synthetic intermediate in various synthesis of pharmaceutical goods.

Technology Process of 5-chloro-2,4-difluoropyrimidine

There total 1 articles about 5-chloro-2,4-difluoropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trifluoro-5-chloropyrimidine (697-83-6) → Di-fluoro-mono-chloro-pyrimidine (25151-07-9)

Guidance literature:

2,4,6-trifluoro-5-chloropyrimidine; With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine; In hexane; at 20 ℃; for 2h;

With hydrogenchloride; In diethyl ether; benzene-d6; Further stages.;

DOI:10.1039/b110128e

Reference yield: 91.0%

Di-fluoro-mono-chloro-pyrimidine (25151-07-9) → 5-chloro-4-fluoropyrimidine-2-amine (1543022-92-9)

Guidance literature:

With acetamidine hydrochloride; sodium hydroxide; In water; dimethyl sulfoxide; at 130 ℃; for 24h; chemoselective reaction; Schlenk technique;

DOI:10.1039/c8ob02129e

upstream raw materials:

2,4,6-trifluoro-5-chloropyrimidine

Downstream raw materials:

5-chloro-4-fluoropyrimidine-2-amine

Refernces