Quinoline, 1,2,3,4-tetrahydro-3-me

Base Information

• Chemical Name: Quinoline, 1,2,3,4-tetrahydro-3-me
• CAS No.: 20668-20-6
• Molecular Formula: C10H13 N
• Molecular Weight: 147.22
• Hs Code.: 2933499090
• Mol file: 20668-20-6.mol

Synonyms:1,2,3,4-Tetrahydro-3-methylquinoline;3-Methyl-1,2,3,4-tetrahydroquinoline

Chemical Property of Quinoline, 1,2,3,4-tetrahydro-3-me

Chemical Property:

• Boiling Point: 117 °C(Press: 15 Torr)
• PKA: 5.13±0.40(Predicted)
• PSA: 12.03000
• Density: 0.9931 g/cm3
• LogP: 2.42870
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

NLT 98% ^*data from raw suppliers

3-Methyl-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinoline, 1,2,3,4-tetrahydro-3-me

There total 6 articles about Quinoline, 1,2,3,4-tetrahydro-3-me which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

carbon monoxide (201230-82-2) + 2-allyl-phenylamine (32704-22-6) → 2,3,4,5-tetrahydro-1Hbenzo[b]azepine (1701-57-1) + 3-methyl-1,2,3,4-tetrahydroquinoline (20668-20-6) + 3-methyl-3,4-dihydroquinolin-2(1H)-one (31883-79-1)

Guidance literature:

With C₂Cl₂O₂Rh^(1-)*C₈H₁₆N₂O₂Rh⁽¹⁺⁾; hydrogen; In toluene; at 100 ℃; for 24h; under 5171.62 - 36201.3 Torr;

DOI:10.1016/j.tetlet.2010.07.048

Reference yield: 46.0%

carbon monoxide (201230-82-2) + 2-allyl-phenylamine (32704-22-6) → 2,3,4,5-tetrahydro-1Hbenzo[b]azepine (1701-57-1) + 3-methyl-1,2,3,4-tetrahydroquinoline (20668-20-6)

Guidance literature:

With C₂Cl₂O₂Rh^(1-)*C₃₂H₃₂N₂O₂Rh⁽¹⁺⁾; hydrogen; In tetrahydrofuran; at 100 ℃; for 24h; under 5171.62 - 36201.3 Torr;

DOI:10.1016/j.tetlet.2010.07.048

Reference yield: 31.0%

carbon monoxide (201230-82-2) + 2-allyl-phenylamine (32704-22-6) → 3-methyl-1,2,3,4-tetrahydroquinoline (20668-20-6) + 3-methyl-3,4-dihydroquinolin-2(1H)-one (31883-79-1)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; N,N,N',N'-tetra(isopropyl)ethylenediamine; hydrogen; In tetrahydrofuran; at 100 ℃; for 24h; under 5171.62 - 36201.3 Torr;

DOI:10.1016/j.tetlet.2010.07.048

upstream raw materials:

3-methylquinoline

tetralin

decalin

carbon monoxide

Downstream raw materials:

1-benzyl-3-methyl-1,2,3,4-tetrahydroquinoline

3-methylquinoline

Refernces

• 1、 Okuro, Kazumi,Alper, Howard. "Ionic diamine rhodium complex catalyzed hydroaminomethylation of 2-allylanilines". scheme or table. p. 4959 - 4961. Retrieved 2011/01/12.