4-Chloro-2-mercaptobenzoic acid

Base Information

• Chemical Name: 4-Chloro-2-mercaptobenzoic acid
• CAS No.: 20324-49-6
• Molecular Formula: C7H5 Cl O2 S
• Molecular Weight: 188.635
• Hs Code.: 2930909090
• Mol file: 20324-49-6.mol

Synonyms:4-Chloro-2-mercaptobenzoicacid

Chemical Property of 4-Chloro-2-mercaptobenzoic acid

Chemical Property:

• Melting Point: 195-196 °C
• Boiling Point: 334.0±27.0 °C(Predicted)
• PKA: 3.31±0.36(Predicted)
• PSA: 76.10000
• Density: 1.490±0.06 g/cm3(Predicted)
• LogP: 2.32690

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-2-mercaptobenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-mercaptobenzoic acid

There total 3 articles about 4-Chloro-2-mercaptobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Amino-4-chlorobenzoic acid (89-77-0) → 2-mercapto-4-chlorobenzoic acid (20324-49-6)

Guidance literature:

2-Amino-4-chlorobenzoic acid; With hydrogenchloride; sodium hydroxide; sodium nitrite; In water; at 0 - 5 ℃; for 0.5h;

With potassium ethyl xanthogenate; In water; at 75 - 80 ℃; for 0.5h;

With hydrogenchloride; sodium hydroxide; water; sodium hydrogensulfite; more than 3 stages;

Reference yield:

→ 2-mercapto-4-chlorobenzoic acid (20324-49-6)

Guidance literature:

With sodium disulfide; water; Erwaermen des Reaktionsprodukts mit Zink-Pulver und Essigsaeure;

DOI:10.1021/ja01137a017

Reference yield:

potassium ethyl xanthogenate (140-89-6) → 2-mercapto-4-chlorobenzoic acid (20324-49-6)

Guidance literature:

With water; Erwaermen des Reaktionsprodukts mit wss. NaOH;

DOI:10.1021/jo50016a019

upstream raw materials:

2-Amino-4-chlorobenzoic acid

potassium ethyl xanthogenate

Downstream raw materials:

2-(benzylthio)-4-chlorobenzoic acid

4,4'-dichloro-2,2'-disulfanediyl-bis-benzoyl chloride

4-chloro-2-(hydroxymethyl)thiophenol

2'-(Benzylthio)-4'-chloracetophenon

Refernces

• 1、 -. "1,3-BENZOTHIAZINONE DERIVATIVE AND USE THEREOF". Page/Page column 20. . Retrieved 2008/06/13.