Multi-step reaction with 7 steps
1: Raney nickel, NaH2PO2 / pyridine; acetic acid; H2O / 1.5 h / Ambient temperature
2: toluene-p-sulfonic acid monohydrate / CH2Cl2; acetone / 1) 0 deg C --> room temperature, 30 min; 2) room temperature
3: 1.) potassium tert-butoxide / 1) 1,2-dimethoxyethane, -35 deg C; 2) 1,2-dimethoxyethane, -35 deg C, 30 min
4: 42 percent / POCl3, Et3N / 1,2-dimethoxy-ethane / 1 h / -5 °C
5: sodium methoxide / 1,2-dimethoxy-ethane; methanol / 0.5 h
6: dimethylformamide / 10 h / 45 °C
7: hydrogen peroxide (30percent) / methanol; dioxane / 0.5 h / pH 9.0
With
sodium hypophosphite; potassium tert-butylate; dihydrogen peroxide; sodium methylate; nickel; toluene-4-sulfonic acid; triethylamine; trichlorophosphate;
In
1,4-dioxane; pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;