tert-Butyl 4-(3-hydroxy-1-propyl)benzoate

Base Information

• Chemical Name: tert-Butyl 4-(3-hydroxy-1-propyl)benzoate
• CAS No.: 126931-32-6
• Molecular Formula: C₁₄H₂₀O₃
• Molecular Weight: 236.311
• Mol file: 126931-32-6.mol

Synonyms:tert-Butyl 4-(3-hydroxy-1-propyl)benzoate

Chemical Property of tert-Butyl 4-(3-hydroxy-1-propyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 4-(3-hydroxy-1-propyl)benzoate

There total 11 articles about tert-Butyl 4-(3-hydroxy-1-propyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate (126931-31-5) → tert-Butyl 4-(3-hydroxy-1-propyl)benzoate (126931-32-6)

Guidance literature:

With lithium borohydride; In diethyl ether; for 15h; Ambient temperature;

DOI:10.1021/jo00059a016

Reference yield: 97.0%

3-<4-(tert-butoxycarbonyl)phenyl>propionic acid (86208-18-6) → tert-Butyl 4-(3-hydroxy-1-propyl)benzoate (126931-32-6)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00037a012

Reference yield: 93.0%

tert-butyl 4-(3-hydroxyprop-1-yn-1-yl)benzoate (169134-89-8) → tert-Butyl 4-(3-hydroxy-1-propyl)benzoate (126931-32-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 4h; under 2585.7 Torr;

DOI:10.1021/jo00129a040

upstream raw materials:

methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate

3-<4-(tert-butoxycarbonyl)phenyl>propionic acid

tert-butyl 4-(3-hydroxyprop-1-yn-1-yl)benzoate

4-iodobenzoic acid

Downstream raw materials:

tert-butyl 4-(4-methoxy-3-butenyl)benzoate

4-(4,4-Dicyano-3-dimethoxymethyl-butyl)-benzoic acid tert-butyl ester

4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid

4-[4,4-Dimethoxy-3-(2,4,6-triamino-pyrimidin-5-yl)-butyl]-benzoic acid tert-butyl ester

Refernces

• 1、 Taylor, Edward C.,Young, Wendy B.. "Pyrrolopyrimidine Folate Analogues: "Inverted" Analogues of the Cytotoxic Agent LY231514". . p. 7947 - 7952. Retrieved 2007/10/03.
• 2、 Miwa, Tetsuo,Hitaka, Takenori,Akimoto, Hiroshi. "A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates". . p. 1696 - 1701. Retrieved 2007/10/02.