7-Methoxy-1-tetralone Oxime

Base Information

• Chemical Name: 7-Methoxy-1-tetralone Oxime
• CAS No.: 20175-97-7
• Molecular Formula: C11H13 N O2
• Molecular Weight: 191.23
• Hs Code.: 2928000090
• Mol file: 20175-97-7.mol

Synonyms:7-Methoxy-1-tetraloneoxime

Chemical Property of 7-Methoxy-1-tetralone Oxime

Chemical Property:

• Vapor Pressure: 6.43E-06mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 363.4°C at 760 mmHg
• Flash Point: 173.6°C
• PSA: 41.82000
• Density: 1.19g/cm³
• LogP: 2.20980
• Solubility.: Acetone, Chloroform, Dichloromethane, DMSO

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxy-1-tetraloneOxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Methoxy-1-tetralone Oxime (cas# 20175-97-7) is a compound useful in organic synthesis.

Technology Process of 7-Methoxy-1-tetralone Oxime

There total 5 articles about 7-Methoxy-1-tetralone Oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-Methoxy-1-tetralone (6836-19-7) → 7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime (20175-97-7)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In methanol; for 16h; Reflux;

DOI:10.1016/j.bmcl.2011.04.013

Reference yield:

4-(3-methoxy-phenyl)-4-oxo-butyric acid (38102-67-9) → 7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime (20175-97-7)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / acetic acid / 70 °C

2: polyphosphoric acid / 90 °C

3: sodium acetate; hydroxylamine hydrochloride / methanol / 2 h / 60 °C

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium acetate; In methanol; acetic acid;

DOI:10.1039/c6cc01200k

Reference yield:

methoxybenzene (100-66-3) → 7-methoxy-3,4-dihydronaphthalen-1(2H)-one oxime (20175-97-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / nitrobenzene / 0.5 h / 20 °C

1.2: 60 °C

2.1: palladium 10% on activated carbon; hydrogen / acetic acid / 70 °C

3.1: polyphosphoric acid / 90 °C

4.1: sodium acetate; hydroxylamine hydrochloride / methanol / 2 h / 60 °C

With aluminum (III) chloride; palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; sodium acetate; In methanol; acetic acid; nitrobenzene;

DOI:10.1039/c6cc01200k

upstream raw materials:

7-Methoxy-1-tetralone

4-(3-methoxy-phenyl)-4-oxo-butyric acid

methoxybenzene

4-(m-methoxyphenyl)butanoic acid

Downstream raw materials:

7-methoxy-1-tetralone O-tosyloxime

8-methoxy-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one

C₁₈H₁₆ClF₃N₂O₂

N-(7-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)diphenylacetamide

Refernces

• 1、 -. "Benzo Annulenes as Antiviral Agents". Paragraph 0582-0583. . Retrieved 2018/08/29.
• 2、 Zhang, Minmin,Yu, Shuowen,Hu, Fangzhi,Liao, Yijun,Liao, Lihua,Xu, Xiaoying,Yuan, Weicheng,Zhang, Xiaomei. "Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid". supporting information. p. 8757 - 8760. Retrieved 2016/07/15.