7,3',4'-trimethoxyflavanone

Base Information

• Chemical Name: 7,3',4'-trimethoxyflavanone
• CAS No.: 10493-09-1
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.338
• Mol file: 10493-09-1.mol

Synonyms:7,3',4'-trimethoxyflavanone

Chemical Property of 7,3',4'-trimethoxyflavanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7,3',4'-trimethoxyflavanone

There total 18 articles about 7,3',4'-trimethoxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2'-hydroxy-3,4,4'-trimethoxychalcone (57601-14-6) → 7,3',4'-trimethoxyflavanone (10493-09-1)

Guidance literature:

With bismuth(III) chloride; silica gel; at 70 - 80 ℃;

Reference yield: 80.0%

3,4-Dimethoxyphenylboronic acid (122775-35-3) + 7-methoxy-chroman-4-one (42327-52-6) → 7,3',4'-trimethoxyflavanone (10493-09-1)

Guidance literature:

7-methoxy-chroman-4-one; With [2,2]bipyridinyl; palladium(II) trifluoroacetate; oxygen; In 1,4-dioxane; dimethyl sulfoxide; at 100 ℃; for 21h;

3,4-Dimethoxyphenylboronic acid; With trifluoroacetic acid; In 1,4-dioxane; dimethyl sulfoxide; at 80 ℃; for 15h;

DOI:10.1021/acs.joc.9b01162

Reference yield: 48.0%

3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-1-propanone (76672-90-7) → 7,3',4'-trimethoxyflavanone (10493-09-1)

Guidance literature:

3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-1-propanone; With palladium(II) trifluoroacetate; copper diacetate; In dimethyl sulfoxide; at 100 ℃; for 15h; Inert atmosphere;

With hydrogenchloride; In water; dimethyl sulfoxide; ethyl acetate; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d1ra01672e

upstream raw materials:

diiodomethane

2'-hydroxy-3,4,4'-trimethoxychalcone

but-1-yne

dimethyl sulfate

Downstream raw materials:

7,3',4'-trimethoxyflavan-4-ol

4-(3,4-dimethoxyphenyl)-7-methoxy-4H-benzopyran[4,3-d][1,2,3]selenadiazole

C₁₉H₂₁N₃O₅

C₂₅H₂₅NO₇S

Refernces

• 1、 Cho, Yang Yil,Jang, Hyu Jeong,Kim, Dong Hwan,Kim, Nam Yong,Kim, Nam-Jung,Kim, Young Min,Lee, Soo Jin,Lee, Yong Sup,Park, Boyoung Y.,Son, Seung Hwan,Yoo, Hyung-Seok. "Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids". . p. 10012 - 10023. Retrieved 2019/08/30.
• 2、 Singh, Om V.,Muthukrishnan,Sunderavadivelu. "Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate". . p. 2575 - 2581. Retrieved 2007/10/03.