(S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride

Base Information

• Chemical Name: (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride
• CAS No.: 80971-81-9
• Molecular Formula: C₃₁H₄₂N₄O₅*ClH
• Molecular Weight: 587.159
• Mol file: 80971-81-9.mol

Synonyms:(S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride

Chemical Property of (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride

There total 2 articles about (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-4-Methyl-2-((S)-3-phenyl-2-{2-[(1-phenylsulfanylamino-cyclopropanecarbonyl)-amino]-acetylamino}-propionylamino)-pentanoic acid 2,4,6-trimethyl-benzyl ester → (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride (80971-81-9)

Guidance literature:

With hydrogenchloride; for 0.5h; Ambient temperature;

Reference yield:

1-(o-nitrophenylthio)aminocyclopropane-1-carbonylglycine p-nitrophenyl ester → (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride (80971-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / Ambient temperature

2: 99 percent / 1 M methanolic HCl / 0.5 h / Ambient temperature

With hydrogenchloride; triethylamine; In N,N-dimethyl-formamide;

Reference yield: 98.0%

(S)-3-(4-acetoxyphenyl)-2-[N-(tert.butoxycarbonyl)amino]propionic acid (80971-82-0) + (S)-2-((S)-2-{2-[(1-Amino-cyclopropanecarbonyl)-amino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid 2,4,6-trimethyl-benzyl ester; hydrochloride (80971-81-9) → 1-(t-butyloxycarbonyl-O-acetyl-L-tyrosyl)aminocyclopropane-1-carbonylglycyl-L-phenylalanyl-L-leucine 2,4,6-trimethylbenzyl ester (80971-83-1)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

Downstream raw materials:

1-(t-butyloxycarbonyl-O-acetyl-L-tyrosyl)aminocyclopropane-1-carbonylglycyl-L-phenylalanyl-L-leucine 2,4,6-trimethylbenzyl ester

1-(L-tyrosyl)aminocyclopropane-1-carbonylglycyl-L-phenylalanyl-L-leucine

(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Refernces