Technology Process of C13H7BrF2N2O
There total 3 articles about C13H7BrF2N2O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-bromo-2,5-difluorophenyl)methanol;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
3-bromo-4-cyanopyridine;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
1.3: pH 2
2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
3.2: 4 h / 0 °C
With
n-butyllithium; dimethylsulfide borane complex; sodium hydride;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.2: 4 h / 0 °C
With
dimethylsulfide borane complex; sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;