C₄₅H₆₂O₁₂

Base Information

• Chemical Name: C₄₅H₆₂O₁₂
• CAS No.: 848854-52-4
• Molecular Formula: C₄₅H₆₂O₁₂
• Molecular Weight: 794.98
• Mol file: 848854-52-4.mol

Synonyms:C₄₅H₆₂O₁₂

Chemical Property of C₄₅H₆₂O₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₆₂O₁₂

There total 18 articles about C₄₅H₆₂O₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C45H60O11 (848854-50-2) → C45H62O12 (848854-52-4)

Guidance literature:

With water; toluene-4-sulfonic acid; In benzene; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetasy.2004.11.028

Reference yield:

(25R)-2α-hydroxy-5α-spirostan-3-one (848854-25-1) → C45H62O12 (848854-52-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 7.5 g / pyridine / CH₂Cl₂ / 2 h / -40 - 0 °C

2.1: 63 percent / sodium borohydride / methanol; tetrahydrofuran / 0.5 h / 20 °C

3.1: 74 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.58 h / 0 °C

4.1: 73 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾-CHCl₃ adduct; 1,2-bis(diphenylphosphino)ethane / tetrahydrofuran / 6 h / 50 °C

5.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

6.1: 29 percent / NBS; H₂O; epichlorohydrin / 1,2-dimethoxy-ethane / 2.5 h / 0 - 20 °C

7.1: NaHCO₃

7.2: 70 percent / Bu₂SnO

8.1: 74 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

9.1: 128 mg / sodium hydride / hexamethylphosphoric acid triamide / 6 h / 60 °C

10.1: 64 percent / H₂O; p-toluenesulfonic acid monohydrate / benzene / 0.33 h / 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; boron trifluoride diethyl etherate; water; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; epichlorohydrin; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; dichloromethane; benzene; 3.1: Ferrier reaction;

DOI:10.1016/j.tetasy.2004.11.028

Reference yield:

(25R)-3-trimethylsilyloxy-5α-spirost-2-ene (881175-98-0) → C45H62O12 (848854-52-4)

Guidance literature:

Multi-step reaction with 11 steps

1.1: dimethyldioxirane / acetone; CH₂Cl₂ / 0.83 h / 0 °C

2.1: 7.5 g / pyridine / CH₂Cl₂ / 2 h / -40 - 0 °C

3.1: 63 percent / sodium borohydride / methanol; tetrahydrofuran / 0.5 h / 20 °C

4.1: 74 percent / BF₃*OEt₂ / CH₂Cl₂ / 0.58 h / 0 °C

5.1: 73 percent / tris(dibenzylideneacetone)dipalladium⁽⁰⁾-CHCl₃ adduct; 1,2-bis(diphenylphosphino)ethane / tetrahydrofuran / 6 h / 50 °C

6.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 24 h / 20 °C

7.1: 29 percent / NBS; H₂O; epichlorohydrin / 1,2-dimethoxy-ethane / 2.5 h / 0 - 20 °C

8.1: NaHCO₃

8.2: 70 percent / Bu₂SnO

9.1: 74 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

10.1: 128 mg / sodium hydride / hexamethylphosphoric acid triamide / 6 h / 60 °C

11.1: 64 percent / H₂O; p-toluenesulfonic acid monohydrate / benzene / 0.33 h / 20 °C

With pyridine; sodium tetrahydroborate; N-Bromosuccinimide; boron trifluoride diethyl etherate; water; 3,3-dimethyldioxirane; sodium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; epichlorohydrin; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; dichloromethane; acetone; benzene; 4.1: Ferrier reaction;

DOI:10.1016/j.tetasy.2004.11.028

upstream raw materials:

C₄₅H₆₀O₁₁

(25R)-2α-hydroxy-5α-spirostan-3-one

(25R)-3-trimethylsilyloxy-5α-spirost-2-ene

(25R)-2α-allyloxycarbonyloxy-5α-spirostan-3-one

Refernces