Androst-5-en-17-one, 3,7,15-trihydroxy-, (3beta,7alpha,15alpha)- (9CI)

Base Information

• Chemical Name: Androst-5-en-17-one, 3,7,15-trihydroxy-, (3beta,7alpha,15alpha)- (9CI)
• CAS No.: 2963-69-1
• Molecular Formula: C19H28O4
• Molecular Weight: 320.429
• Mol file: 2963-69-1.mol

Synonyms:Androst-5-en-17-one,3b,7a,15a-trihydroxy- (7CI,8CI);3b,7a,15a-Trihydroxyandrost-5-en-17-one;

Chemical Property of Androst-5-en-17-one, 3,7,15-trihydroxy-, (3beta,7alpha,15alpha)- (9CI)

Chemical Property:

• Vapor Pressure: 0.001Pa at 25℃
• Boiling Point: 517.456 °C at 760 mmHg
• PKA: 13.77±0.70(Predicted)
• Flash Point: 280.831 °C
• PSA: 77.76000
• Density: 1.267 g/cm³
• LogP: 1.82080
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3b,7a,15a-Trihydroxyandrost-5-en-17-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Progestin therapeutic

Technology Process of Androst-5-en-17-one, 3,7,15-trihydroxy-, (3beta,7alpha,15alpha)- (9CI)

There total 3 articles about Androst-5-en-17-one, 3,7,15-trihydroxy-, (3beta,7alpha,15alpha)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

dehydroepiandrosterone (53-43-0) → 3β,7α-dihydroxyandrost-5-ene-17-one (2487-48-1,7522-54-5,62357-03-3,53-00-9) + 3β,7α,15α-trihydroxy-5-androstene-17-one (2963-69-1)

Guidance literature:

With randomly methylated β-cyclodextrin; In water; N,N-dimethyl-formamide; at 29 ℃; for 30h; pH=6.0;

DOI:10.1016/j.steroids.2008.10.019

Reference yield:

dehydroepiandrosterone (53-43-0) → 3β,7α-dihydroxyandrost-5-ene-17-one (2487-48-1,7522-54-5,62357-03-3,53-00-9) + 3β,7α,15α-trihydroxy-5-androstene-17-one (2963-69-1) + 3β,15β-dihydroxyandrost-5-en-17-one

Guidance literature:

With glucose dehydrogenase; 2,3,4,5,6-pentahydroxy-hexanal; Bacillus megaterium P₄₅₀BM₃ enzyme GV A₁₈₄I I₂₆₃G A₃₂₈G variant; In aq. phosphate buffer; at 20 ℃; for 16h; pH=7.9; Catalytic behavior; Enzymatic reaction;

DOI:10.1021/acscatal.0c02077

Reference yield:

→ 3β,7α,15α-Trihydroxy-androst-5-en-17-on (2963-69-1,85390-93-8)

Guidance literature:

3β-Hydroxy-5-androsten-17-on, enzymat. Hydroxylierung;

upstream raw materials:

dehydroepiandrosterone

Downstream raw materials:

7β-hydroxy-3β,15α-dipivaloyloxy-5-androsten-17-one

C₂₂H₃₂O₄

3β,7β,15α-trihydroxy-5-androsten-17-one

7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one

Refernces

• 1、 Wu, Yan,Li, Hui,Lu, Zhen-Ming,Li, Heng,Rao, Zhi-Ming,Geng, Yan,Shi, Jin-Song,Xu, Zheng-Hong. "Enhancement of steroid hydroxylation yield from dehydroepiandrosterone by cyclodextrin complexation technique". . p. 70 - 77. Retrieved 2014/05/06.