2-(3-METHOXY-PHENYLAMINO)-ETHANOL

Base Information

• Chemical Name: 2-(3-METHOXY-PHENYLAMINO)-ETHANOL
• CAS No.: 2933-76-8
• Molecular Formula: C9H13 N O2
• Molecular Weight: 167.208
• Hs Code.: 2922509090
• Mol file: 2933-76-8.mol

Synonyms:Ethanol,2-m-anisidino- (7CI,8CI); N-(b-Hydroxyethyl)-m-anisidine

Chemical Property of 2-(3-METHOXY-PHENYLAMINO)-ETHANOL

Chemical Property:

• PSA: 41.49000
• LogP: 1.17240

Purity/Quality:

99%min ^*data from raw suppliers

2-(3-METHOXY-PHENYLAMINO)-ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-METHOXY-PHENYLAMINO)-ETHANOL

There total 7 articles about 2-(3-METHOXY-PHENYLAMINO)-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-methoxyphenyl bromide (2398-37-0) + ethanolamine (141-43-5) → 2-((3-methoxyphenyl)amino)ethanol (2933-76-8)

Guidance literature:

With potassium phosphate; copper(l) iodide; L-proline; In dimethyl sulfoxide; at 80 ℃; for 29h;

DOI:10.1021/jo0504464

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) + ethanolamine (141-43-5) → 2-((3-methoxyphenyl)amino)ethanol (2933-76-8)

Guidance literature:

3-methoxy-1-iodobenzene; With copper(l) iodide; L-proline; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h; Inert atmosphere;

ethanolamine; In dimethyl sulfoxide; at 20 ℃; for 40h; Inert atmosphere;

DOI:10.1002/cctc.201501375

Reference yield:

m-Anisidine (536-90-3,918666-97-4) + 2-Chloroethyl chloroformate (627-11-2) → 2-((3-methoxyphenyl)amino)ethanol (2933-76-8)

Guidance literature:

m-Anisidine; 2-Chloroethyl chloroformate; With pyridine; In dichloromethane; at 20 ℃; Inert atmosphere;

With potassium hydroxide; In ethanol; at 90 ℃; for 5h; Inert atmosphere;

DOI:10.1002/anie.201602020

upstream raw materials:

3-methoxyphenyl bromide

ethanolamine

m-Anisidine

3-(3-methoxyphenyl)-2-oxazolidinone

Downstream raw materials:

5-bromo-[N-(2-hydroxyethyl)-N-(3-methoxyphenyl)]nicotinamide

2-[(3-methoxyphenyl)-N-methylamino]ethanol

Refernces

• 1、 Solé, Daniel,Mariani, Francesco,Bennasar, M.-Llu?sa,Fernández, Israel. "Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds". supporting information. p. 6467 - 6470. Retrieved 2016/06/01.
• 2、 Andreoli, Mirko,Persico, Marco,Kumar, Ajay,Orteca, Nausicaa,Kumar, Vineet,Pepe, Antonella,Mahalingam, Sakkarapalayam,Alegria, Antonio E.,Petrella, Lella,Sevciunaite, Laima,Camperchioli, Alessia,Mariani, Marisa,Di Dato, Antonio,Novellino, Ettore,Scambia, Giovanni,Malhotra, Sanjay V.,Ferlini, Cristiano,Fattorusso, Caterina. "Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells". . p. 7916 - 7932. Retrieved 2014/12/10.