2-(Pyridin-2-yl)aniline

Base Information

• Chemical Name: 2-(Pyridin-2-yl)aniline
• CAS No.: 29528-30-1
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90952024
• Nikkaji Number: J88.607F
• Wikidata: Q72440905
• Mol file: 29528-30-1.mol

Synonyms:2-(pyridin-2-yl)aniline;29528-30-1;2-(2-Pyridyl)aniline;2-pyridin-2-ylaniline;2-Pyridin-2-yl-phenylamine;benzenamine, 2-(2-pyridinyl)-;2-(2-Pyridinyl)Benzenamine;2-(pyridin-2-yl)benzenamine;Benzenamine,2-(2-pyridinyl)-;(aminophenyl)pyridine;2-(2-Pyridinyl)aniline;ortho-(2-pyridyl)aniline;2-(o-Aminophenyl)pyridine;2-(2-Aminophenyl)pyridine;SCHEMBL819951;SCHEMBL9207301;DTXSID90952024;BCP32482;MFCD03426328;AKOS012990188;AB14825;BS-22243;BB 0260519;CS-0213295;FT-0682359;N12890;J-506579;2-(2-pyridinyl)Benzenamine;6048-22-2

Chemical Property of 2-(Pyridin-2-yl)aniline

Chemical Property:

• Vapor Pressure: 0.000335mmHg at 25°C
• Refractive Index: 1.625
• Boiling Point: 319.6 °C at 760 mmHg
• Flash Point: 173 °C
• PSA: 38.91000
• Density: 1.133 g/cm³
• LogP: 2.91200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 170.084398327
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

2-(Pyridin-2-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=CC=CC=N2)N

Technology Process of 2-(Pyridin-2-yl)aniline

There total 32 articles about 2-(Pyridin-2-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-(pyridin-2-yl)phenyl)isoindoline-1,3-dione (1446325-77-4) → 2-(2-pyridyl)aniline (29528-30-1)

Guidance literature:

With hydrazine hydrate; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol401569u

Reference yield: 98.0%

2-bromo-pyridine (109-04-6) + 2-aminophenylboronic acid (5570-18-3) → 2-(2-pyridyl)aniline (29528-30-1)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 5h; Inert atmosphere;

DOI:10.1002/cmdc.202000841

Reference yield: 95.0%

N-(tert-butyloxycarbonyl)-2-(pyridin-2-yl)aniline (1318768-17-0) → 2-(2-pyridyl)aniline (29528-30-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ol401209f

upstream raw materials:

2-(2-nitrophenyl)pyridine

2-(2-azidophenyl)pyridine

decalin

2-bromo-pyridine

Downstream raw materials:

2-(2-azidophenyl)pyridine

ethyl (E)-2-<2-(pyridin-2'-yl)phenylhydrazono>propanoate

Dithiocarbonic acid O-ethyl ester S-(2-pyridin-2-yl-phenyl) ester

2-nitro-N-(2-(pyridin-2-yl)phenyl)benzenesulfonamide

Refernces

• 1、 Usui, Kensuke,Nakada, Masahisa. "Facile formation of imidazolinium salt by reaction of corresponding diamine and trimethyl orthoformate in 1,1,1,3,3,3-hexafluoroisopropanol". . p. 1539 - 1551. Retrieved 2014.
• 2、 Polomski, Marion,Brachet-Botineau, Marie,Juen, Ludovic,Viaud-Massuard, Marie-Claude,Gouilleux, Fabrice,Prié, Gildas. "Inhibitors Targeting STAT5 Signaling in Myeloid Leukemias: New Tetrahydroquinoline Derivatives with Improved Antileukemic Potential". supporting information. p. 1034 - 1046. Retrieved 2021/01/25.
• 3、 Gao, Hui,Li, Xingwei,Sun, Jiaqiong,Xu, Youwei,Zheng, Guangfan,Zhou, Xukai. "Rhodium(III)-catalyzed chelation-assisted C-H imidation of arenes via umpolung of the imidating reagent". . p. 1723 - 1733. Retrieved 2020/05/05.