GUANFACINE HCL

Base Information

• Chemical Name: GUANFACINE HCL
• CAS No.: 29520-14-7
• Molecular Formula: C₉H₉Cl₂N₃O*ClH
• Molecular Weight: 282.557
• Mol file: 29520-14-7.mol

Synonyms:Acetamide,N-amidino-2-(2,6-dichlorophenyl)-, hydrochloride (8CI)

Chemical Property of GUANFACINE HCL

Chemical Property:

• PSA: 78.97000
• LogP: 3.53850
• Solubility.: H2O: 12 mg/mL at 60 °C, soluble

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GUANFACINE HCL

There total 2 articles about GUANFACINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

methyl 2-(2,6-dichlorophenyl)acetate (54551-83-6) + guanidine hydrochloride (50-01-1) → guanfacine hydrochloride (29110-48-3,29520-14-7)

Guidance literature:

In ethanol; at 20 ℃; for 30h;

Reference yield:

guanfacine (29110-47-2) → guanfacine hydrochloride (29110-48-3,29520-14-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 0.5h; pH=1;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + guanfacine hydrochloride (29110-48-3,29520-14-7) → guanfacine tert-butyl carbamate hydrochloride (1364788-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 22 °C

2: hydrogenchloride / diethyl ether / 0.02 h

With hydrogenchloride; triethylamine; In diethyl ether; N,N-dimethyl-formamide;

upstream raw materials:

guanfacine

methyl 2-(2,6-dichlorophenyl)acetate

guanidine hydrochloride

Downstream raw materials:

guanfacine tert-butyl carbamate hydrochloride

Refernces

• 1、 -. "The preparation method of the overall tablet sizes hydrochloride (by machine translation)". Paragraph 0027; 0028; 0029. . Retrieved 2017/08/29.