BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&

Base Information

• Chemical Name: BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&
• CAS No.: 29518-68-1
• Molecular Formula: C9H11 N3
• Molecular Weight: 161.206
• Hs Code.: 2933990090
• Mol file: 29518-68-1.mol

Synonyms:Benzimidazole,2-(2-aminoethyl)- (6CI,7CI,8CI); 2-(1H-Benzimidazol-2-yl)ethylamine;2-(2-Aminoethyl)benzimidazole; 2-(Aminoethyl)-1H-benzimidazole

Chemical Property of BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&

Chemical Property:

• Melting Point: 160℃
• Boiling Point: 400°Cat760mmHg
• PKA: 11.82±0.10(Predicted)
• Flash Point: 224.5°C
• PSA: 54.70000
• Density: 1.225g/cm³
• LogP: 1.76440
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(1H-Benzo[d]imidazol-2-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Polymer-supported Wittig reagent for clean olefinations of carbonyl compounds.

Technology Process of BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&

There total 10 articles about BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,2-diamino-benzene (95-54-5) + 3-amino propanoic acid (107-95-9) → 2-(1H-benzimidazol-2-yl)ethylamine (29518-68-1)

Guidance literature:

With hydrogenchloride; In water; for 5h; Reflux;

DOI:10.1016/j.bmc.2013.10.052

Reference yield:

2-(1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (4499-07-4) → 2-(1H-benzimidazol-2-yl)ethylamine (29518-68-1)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 0.5h;

Reference yield:

1H-benzimidazol-2-acetonitrile (4414-88-4) → 2-(1H-benzimidazol-2-yl)ethylamine (29518-68-1)

Guidance literature:

With hydrogenchloride; sodium amalgam; water;

upstream raw materials:

1H-benzimidazol-2-acetonitrile

[2-(1H-benzoimidazol-2-yl)-ethyl]-carbamic acid ethyl ester

N-(2-(1H-benzimidazole-2-yl)ethyl)benzamide

1,2-diamino-benzene

Downstream raw materials:

2-[2-(1H-benzimidazol-2-yl)ethyl]-1H-isoindole-1,3(2H)-dione

2-[2-(1H-Benzoimidazol-2-yl)-ethyl]-4-nitro-isoindole-1,3-dione

6,7,8,9-Tetrahydro-5H-4b,7,10-triaza-benzo[a]azulene

(2R,3R,4S,5R)-2-{6-[2-(1H-Benzoimidazol-2-yl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol

Refernces

• 1、 Elshihawy, Hosam,Helal, Mohamed A.,Said, Mohamed,Hammad, Mohamed A.. "Design, synthesis, and enzyme kinetics of novel benzimidazole and quinoxaline derivatives as methionine synthase inhibitors". . p. 550 - 558. Retrieved 2014/01/17.
• 2、 Cantrell, Amanda S.,Engelhardt, Per,H?gberg, Marita,Jaskunas, S. Richard,Johansson, Nils Gunnar,Jordan, Christopher L.,Kangasmets?, Jussi,Kinnick, Michael D.,Lind, Peter,Morin Jr., John M.,Muesing,Noreén, Rolf,?berg, Bo,Pranc, Paul,Sahlberg, Christer,Ternansky, Robert J.,Vasileff, Robert T.,Vrang, Lotta,West, Sarah J.,Zhang, Hong. "Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs". . p. 4261 - 4274. Retrieved 2007/10/03.