4-chloro-2,6-diphenylpyrimidine

Base Information

• Chemical Name: 4-chloro-2,6-diphenylpyrimidine
• CAS No.: 29509-91-9
• Molecular Formula: C16H11ClN2
• Molecular Weight: 266.73
• Hs Code.: 2933599090
• Mol file: 29509-91-9.mol

Synonyms:6-Chloro-2,4-diphenylpyrimidine;4-Chloro-2,6-diphenylpyrimidine;pyrimidine, 4-chloro-2,6-diphenyl-;

Chemical Property of 4-chloro-2,6-diphenylpyrimidine

Chemical Property:

• Vapor Pressure: 0.000184mmHg at 25°C
• Melting Point: 104-105℃
• Refractive Index: 1.617
• Boiling Point: 339.2 °C at 760 mmHg
• PKA: -0.99±0.30(Predicted)
• Flash Point: 189.4 °C
• PSA: 25.78000
• Density: 1.221 g/cm³
• LogP: 4.46400
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4-Chloro-2,6-diphenylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2,6-diphenylpyrimidine

There total 8 articles about 4-chloro-2,6-diphenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,6-diphenyl-3H-pyrimidin-4-one (15969-46-7) → 4-chloro-2,6-diphenyl-1,3-pyrimidine (29509-91-9)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 3h; Heating;

DOI:10.1071/CH9840155

Reference yield: 75.0%

fenclorim (3740-92-9) + phenylboronic acid (98-80-6) → 4-chloro-2,6-diphenyl-1,3-pyrimidine (29509-91-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 73.0%

→ 4-chloro-2,6-diphenyl-1,3-pyrimidine (29509-91-9)

Guidance literature:

With iodine; magnesium; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere; Reflux;

In tetrahydrofuran; at 0 ℃;

upstream raw materials:

2,6-diphenyl-3H-pyrimidin-4-one

benzamidine monohydrochloride

ethyl 3-oxo-3-phenylpropionate

2,4,6-trichloropyrimidine

Downstream raw materials:

4-(2,6-diphenyl-pyrimidin-4-ylamino)-N-methyl-benzenesulfonamide

Refernces

• 1、 -. "Compound, high polymer, mixture, composition and organic electronic device". Paragraph 0251-0256. . Retrieved 2020/11/12.
• 2、 -. "COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT COMPRISING THE SAME AND ELECTRONIC DEVICE THEREOF". Paragraph 0222; 0223. . Retrieved 2018/10/21.