N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

Base Information

• Chemical Name: N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE
• CAS No.: 2875-41-4
• Molecular Formula: C₅H₁₂N₂O₂
• Molecular Weight: 132.162
• Hs Code.: 2922499990
• Mol file: 2875-41-4.mol

Synonyms:3,7-Diazaheptanoicacid

Chemical Property of N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

Chemical Property:

• Boiling Point: 287.8±20.0 °C(Predicted)
• PKA: 2.27±0.10(Predicted)
• PSA: 75.35000
• Density: 1.118±0.06 g/cm3(Predicted)
• LogP: 1.70460

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

There total 4 articles about N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trimethylenediamine (109-76-2,54018-94-9) + chloroacetic acid (79-11-8) → N-(3-aminopropyl)glycine (2875-41-4)

Guidance literature:

DOI:10.1039/c39930000518

Reference yield:

Trimethylenediamine (109-76-2,54018-94-9) → N-(3-aminopropyl)glycine (2875-41-4)

Guidance literature:

at 25 ℃; for 48h; Yield given;

DOI:10.1021/jo00047a022

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + sodium cyanide (143-33-9,25596-52-5) + Trimethylenediamine (109-76-2,54018-94-9) → N-(3-aminopropyl)glycine (2875-41-4)

Guidance literature:

Multistep reaction; (i) H₂O, (ii) /BRN= 1209228/;

DOI:10.1021/ja00750a038

upstream raw materials:

formaldehyd

sodium cyanide

Trimethylenediamine

bromoacetic acid

Downstream raw materials:

(2-iminotetrahydro-pyrimidin-1(2H)-yl)acetic acid

[(3-Benzyloxycarbonylamino-propyl)-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-amino]-acetic acid methyl ester

(3-Benzyloxycarbonylamino-propylamino)-acetic acid methyl ester

Refernces

• 1、 -. "SYNTHESIS OF CYCLOCREATINE AND ANALOGS THEREOF". Paragraph 0046. . Retrieved 2016/09/26.
• 2、 Byk, Gerardo,Gilon, Chaim. "Building Units for N-Backbone Cyclic Peptides. 1. Synthesis of Protected N-(ω-Aminoalkylene)amino Acids and Their Incorporation into Dipeptide Units". . p. 5687 - 5692. Retrieved 2007/10/02.