Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid

Base Information

• Chemical Name: Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid
• CAS No.: 151418-18-7
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.241
• Mol file: 151418-18-7.mol

Synonyms:Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid

Chemical Property of Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid

There total 3 articles about Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + chloroformic acid ethyl ester (541-41-3) + 3-Phenylpropionic acid (501-52-0) → Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid (151418-18-7) + N-(3-phenylpropanoyl)-L-Glu-OH

Guidance literature:

chloroformic acid ethyl ester; 3-Phenylpropionic acid; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

L-glutamic acid; With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; for 0.5h; pH=1;

DOI:10.1246/cl.2012.577

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 3-Phenylpropionic acid (501-52-0) → Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid (151418-18-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -7 ℃; for 0.5h;

DOI:10.1055/s-1987-28035

Reference yield:

→ Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid (151418-18-7)

Guidance literature:

Aethylchloroformiat, Dihydrozimtsaeure, Triaethylamin;

DOI:10.1021/bi00764a028

upstream raw materials:

chloroformic acid ethyl ester

3-Phenylpropionic acid

L-glutamic acid

Downstream raw materials:

N-[2-(4-Bromo-2,5-dimethoxy-phenyl)-ethyl]-3-phenyl-propionamide

ethyl (4-mercaptophenyl)carbamate

N-(4-cyanophenyl)-3-phenylpropanamide

N-(4-bromophenyl)-3-phenylpropanamide

Refernces

• 1、 Kawashima, Yuya,Ezawa, Tetsuya,Yamamura, Mai,Harada, Taisuke,Noguchi, Takuya,Imai, Nobuyuki. "Convenient synthesis of (+)-cis-4-(N-adamantyl-N-methylamino)-2,3-methano-2-phenylbutan-1-ol as a candidate of anti-Alzheimer's medicine via catalytic enantioselective Simmons-Smith reaction using l-phenylalanine-derived disulfonamide". . p. 668 - 671. Retrieved 2016.
• 2、 Ezawa, Tetsuya,Kawashima, Yuya,Noguchi, Takuya,Jung, Seunghee,Imai, Nobuyuki. "Convenient synthesis of memantine analogues containing a chiral cyclopropane skeleton as a sigma-1 receptor agonist". . p. 266 - 281. Retrieved 2017/02/18.