5-NITRO-2-THIOMETHYL BENZOXAZOLE

Base Information

• Chemical Name: 5-NITRO-2-THIOMETHYL BENZOXAZOLE
• CAS No.: 2851-07-2
• Molecular Formula: C8H4N2O3S
• Molecular Weight: 208.19396
• Hs Code.: 2934999090
• Mol file: 2851-07-2.mol

Synonyms:5-NITRO-2-THIOMETHYL BENZOXAZOLE

Chemical Property of 5-NITRO-2-THIOMETHYL BENZOXAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.676
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 103.94000
• Density: 1.48g/cm³
• LogP: 2.60700
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(Methylthio)-5-nitrobenzo[d]oxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-NITRO-2-THIOMETHYL BENZOXAZOLE

There total 6 articles about 5-NITRO-2-THIOMETHYL BENZOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-nitro-1,3-benzoaxazolidine-2-thione (22876-21-7) + methyl iodide (74-88-4) → 2-methylsulfanyl-5-nitro-benzooxazole (2851-07-2)

Guidance literature:

In N,N-dimethyl-formamide; at 25 ℃; for 4h;

DOI:10.1016/j.bmcl.2012.06.010

Reference yield: 86.0%

methyl iodide (74-88-4) → 2-methylsulfanyl-5-nitro-benzooxazole (2851-07-2)

Guidance literature:

4-nitro-1,3-benzoaxazolidine-2-thione; With sodium hydride; In tetrahydrofuran; at 5 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield: 82.0%

→ 2-methylsulfanyl-5-nitro-benzooxazole (2851-07-2)

Guidance literature:

upstream raw materials:

diazomethane

4-nitro-1,3-benzoaxazolidine-2-thione

dimethyl sulfate

methyl iodide

Refernces

• 1、 Ongarora, Dennis S.B.,Strydom, Natasha,Wicht, Kathryn,Njoroge, Mathew,Wiesner, Lubbe,Egan, Timothy J.,Wittlin, Sergio,Jurva, Ulrik,Masimirembwa, Collen M.,Chibale, Kelly. "Antimalarial benzoheterocyclic 4-aminoquinolines: Structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies". . p. 5419 - 5432. Retrieved 2015/11/11.
• 2、 -. "Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives". Page/Page column 56. . Retrieved 2010/11/23.