2-FLUOROXANTHEN-9-ONE

Base Information

• Chemical Name: 2-FLUOROXANTHEN-9-ONE
• CAS No.: 2839-49-8
• Molecular Formula: C13H7 F O2
• Molecular Weight: 214.19
• Hs Code.: 2932999099
• Mol file: 2839-49-8.mol

Synonyms:Xanthen-9-one,2-fluoro- (6CI,8CI); 2-Fluoroxanthone; 3-Fluoroxanthone

Chemical Property of 2-FLUOROXANTHEN-9-ONE

Chemical Property:

• PSA: 30.21000
• LogP: 3.08530

Purity/Quality:

98%min ^*data from raw suppliers

2-FLUOROXANTHEN-9-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROXANTHEN-9-ONE

There total 18 articles about 2-FLUOROXANTHEN-9-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(5-fluoro-2-hydroxyphenyl)(2-fluorophenyl)methanone → 2-fluoro-9H-xanthen-9-one (2839-49-8)

Guidance literature:

With potassium carbonate; In butanone; Reflux;

DOI:10.1016/j.bmcl.2009.01.108

Reference yield: 98.0%

2-fluoro-9H-xanthene (714972-01-7) → 2-fluoro-9H-xanthen-9-one (2839-49-8)

Guidance literature:

With tert.-butylnitrite; oxygen; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dichloro-ethane; at 20 ℃; for 18h; Solvent; Irradiation; Schlenk technique; Sealed tube;

DOI:10.1055/s-0037-1610678

Reference yield: 84.0%

2-(4-fluorophenoxy)benzaldehyde (320423-61-8) → 2-fluoro-9H-xanthen-9-one (2839-49-8)

Guidance literature:

With water; copper; Selectfluor; In acetonitrile; at 100 ℃; for 24h;

DOI:10.1016/j.tet.2019.130533

upstream raw materials:

2-(4-fluoro-phenoxy)-benzoic acid

methyl 5-fluoro-2-hydroxybenzoate

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

4-Fluorophenol

Downstream raw materials:

2-fluoro-9H-xanthene

Refernces

• 1、 Chinchilla, Rafael,Torregrosa-Chinillach, Alejandro. "Synthesis of xanthones, thioxanthones and Acridones by a metal-free photocatalytic oxidation using visible light and molecular oxygen". . . Retrieved 2021/06/12.
• 2、 Anna,Chen, Zhaohang,Gao, Juanhong,Li, Chao,Qiao, Hongwei,Zhu, Mengyao. "Synthesis of xanthones from 4-(2-phenoxyphenyl)-1-tosyl-1H-1,2,3-triazole via rhodium-catalyzed annulation/oxidation". . . Retrieved 2021/10/19.