1-(Aminomethyl)cycloheptanol hydrochloride

Base Information

• Chemical Name: 1-(Aminomethyl)cycloheptanol hydrochloride
• CAS No.: 2815-39-6
• Molecular Formula: C8H17 N O . Cl H
• Molecular Weight: 179.69
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID30593773
• Mol file: 2815-39-6.mol

Synonyms:2815-39-6;1-(AMINOMETHYL)CYCLOHEPTANOL HYDROCHLORIDE;1-(Aminomethyl)cycloheptan-1-ol hydrochloride;1-(aminomethyl)-cycloheptanolhydrochloride;1-(aminomethyl)cycloheptan-1-ol;hydrochloride;1-aminomethyl-cycloheptanol hydrochloride;1-(Aminomethyl)-cycloheptanol hydrochloride;SCHEMBL491971;1-aminomethyl-cycloheptanol HCl;1-(aminomethyl)cycloheptanol hcl;DTXSID30593773;OWUQPXVIOASEHZ-UHFFFAOYSA-N;AKOS015900935;DB-067887;1-(aminomethyl)cycloheptan-1-ol,hydrochloride;E79629;1-(AMINOMETHYL)CYCLOHEPTANOLHYDROCHLORIDE;1-(Aminomethyl)cycloheptan-1-ol--hydrogen chloride (1/1)

Chemical Property of 1-(Aminomethyl)cycloheptanol hydrochloride

Chemical Property:

• Melting Point: 223℃
• PSA: 46.25000
• LogP: 2.53270
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 179.1076919
• Heavy Atom Count: 11
• Complexity: 95.4

Purity/Quality:

99% ^*data from raw suppliers

1-(Aminomethyl)cycloheptanolhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCCC(CC1)(CN)O.Cl

Technology Process of 1-(Aminomethyl)cycloheptanol hydrochloride

There total 3 articles about 1-(Aminomethyl)cycloheptanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-((trimethylsilyl)oxy)cycloheptane-1-carbonitrile (91390-82-8) → 1-aminomethyl-cycloheptanol hydrochloride (2815-39-6)

Guidance literature:

1-((trimethylsilyl)oxy)cycloheptane-1-carbonitrile; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃;

Reference yield:

1-(aminomethyl)cycloheptanol (45732-95-4) → 1-aminomethyl-cycloheptanol hydrochloride (2815-39-6)

Guidance literature:

With acetyl chloride; In tetrahydrofuran; isopropyl alcohol; at 10 - 15 ℃; for 0.833333h;

Reference yield:

cycloheptanone (502-42-1) → 1-aminomethyl-cycloheptanol hydrochloride (2815-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc(II) iodide / 2 h / 20 - 25 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 55 - 65 °C

2.2: 1.17 h / 10 - 25 °C

3.1: acetyl chloride / tetrahydrofuran; isopropyl alcohol / 0.83 h / 10 - 15 °C

With lithium aluminium tetrahydride; acetyl chloride; zinc(II) iodide; In tetrahydrofuran; isopropyl alcohol;

upstream raw materials:

1-(aminomethyl)cycloheptanol

1-((trimethylsilyl)oxy)cycloheptane-1-carbonitrile

cycloheptanone

Downstream raw materials:

2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-(5-methyl-1H-pyrazol-3-yl)-benzamide

5-(3,5-Dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-N-(1-hydroxy-cycloheptylmethyl)-2-methyl-benzamide

Refernces

• 1、 -. "Quinoline Derivatives 057". Page/Page column 9. . Retrieved 2009/06/27.