3-(4-Hydroxyphenyl)Propanamide

Base Information

• Chemical Name: 3-(4-Hydroxyphenyl)Propanamide
• CAS No.: 23838-70-2
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID80585320
• Nikkaji Number: J3.243.003A
• Wikidata: Q15726093
• Mol file: 23838-70-2.mol

Synonyms:3-(4-Hydroxyphenyl)Propanamide;23838-70-2;3-(4-Hydroxyphenyl)propionamide;Benzenepropanamide,4-hydroxy-;3-(4-hydroxyphenyl)-propionamide;p-Hydroxybenzylacetamid;4-hydroxybenzenepropanamide;SCHEMBL154384;SCHEMBL8364264;DTXSID80585320;OEHZEBOCZWCVMK-UHFFFAOYSA-N;3-(4-hydroxy-phenyl)-propionamide;MFCD00189404;AKOS006274432;3-(4-hydroxyphenyl)propanoic acid amide;AS-82117;E84720;Q27465352;SGI

Chemical Property of 3-(4-Hydroxyphenyl)Propanamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Boiling Point: 424.8°Cat760mmHg
• Flash Point: 210.7°C
• PSA: 64.31000
• Density: 1.197g/cm³
• LogP: 1.95980
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Hydroxyphenyl)propionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCC(=O)N)O

Technology Process of 3-(4-Hydroxyphenyl)Propanamide

There total 6 articles about 3-(4-Hydroxyphenyl)Propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-hydroxyphenylpropionic acid (501-97-3) → 3-(4-hydroxyphenyl)propanoic acid amide (23838-70-2)

Guidance literature:

4-hydroxyphenylpropionic acid; With thionyl chloride; In methanol;

With ammonium hydroxide; In acetonitrile; at 0 ℃; Reagent/catalyst; Solvent; Temperature;

Reference yield: 72.6%

4-hydroxycinnamic acid amide (194940-15-3) → 3-(4-hydroxyphenyl)propanoic acid amide (23838-70-2)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In water; isopropyl alcohol; at 70 ℃; for 2.5h; under 2250.23 Torr; Temperature; Autoclave; Green chemistry;

Reference yield: 31.0%

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) → 3-(4-hydroxyphenyl)propanoic acid amide (23838-70-2)

Guidance literature:

With ammonia; In water; at 20 ℃; for 15h;

upstream raw materials:

3-(4-hydroxy-phenyl)-propionic acid ethyl ester

3-(4-hydroxyphenyl)propionic acid methyl ester

tert-butyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

4-hydroxyphenylpropionic acid

Downstream raw materials:

trans-2-(4-Acetyloxycyclohexyl)propionitril

3-[4-(3,4-difluoro-benzyloxy)-phenyl]-propionamide

4-hydroxyphenylpropionic acid

3-[3-Allyl-4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-propionamide

Refernces

• 1、 -. "METHOD OF PRODUCING 3-(4-HYDROXYPHENYL) PROPANOIC ACID AMIDE COMPOUND". Paragraph 0059-0061. . Retrieved 2018/10/27.
• 2、 -. "A METHOD OF MANUFACTURING 3-(4-HYDROXYPHENYL)PROPANOIC ACID AMIDE, ITS APPLICATION IN THE MANUFACTURE OF ANTI-AGING COMPOSITIONS AND AN ANTI-AGING COMPOSITION". Page/Page column 7. . Retrieved 2008/06/13.