2H-Azirine-2-carboxamide,3-phenyl-(8CI)

Base Information

• Chemical Name: 2H-Azirine-2-carboxamide,3-phenyl-(8CI)
• CAS No.: 28883-94-5
• Molecular Formula: C9H8 N2 O
• Molecular Weight: 160.175
• Mol file: 28883-94-5.mol

Synonyms:2H-Azirine-2-carboxamide,3-phenyl-(8CI)

Chemical Property of 2H-Azirine-2-carboxamide,3-phenyl-(8CI)

Chemical Property:

• PSA: 55.45000
• LogP: 0.47910

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Azirine-2-carboxamide,3-phenyl-(8CI)

There total 3 articles about 2H-Azirine-2-carboxamide,3-phenyl-(8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-phenyl-isoxazol-5-ylamine (4369-55-5) → 3-phenyl-2H-azirine-2-carboxamide (28883-94-5)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In ethanol; at 20 ℃; Inert atmosphere; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.8b00971

Reference yield:

Benzoylacetonitrile (614-16-4) → 3-phenyl-2H-azirine-2-carboxamide (28883-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C / Inert atmosphere

2: Hoveyda-Grubbs catalyst second generation / ethanol / 20 °C / Inert atmosphere; Schlenk technique; Irradiation

With Hoveyda-Grubbs catalyst second generation; hydroxylamine hydrochloride; sodium acetate; In methanol; ethanol;

DOI:10.1021/acs.orglett.8b00971

Reference yield:

→ 3-phenyl-2H-azirine-2-carboxamide (28883-94-5)

Guidance literature:

5-Amino-3-phenylisooxazol (I), Ethoxyethanol, Erhitzen unter Rueckfluss;

DOI:10.1039/j39700001825

upstream raw materials:

Benzoylacetonitrile

3-phenyl-isoxazol-5-ylamine

Refernces

• 1、 -. "Synthetic method of alpha-amino acid derivative". Paragraph 0021-0023; 0025. . Retrieved 2019/08/03.