2-fluoro-2-phenylmalononitrile

Base Information

• Chemical Name: 2-fluoro-2-phenylmalononitrile
• CAS No.: 1961-36-0
• Molecular Formula: C₉H₅FN₂
• Molecular Weight: 160.151
• Mol file: 1961-36-0.mol

Synonyms:2-fluoro-2-phenylmalononitrile

Chemical Property of 2-fluoro-2-phenylmalononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluoro-2-phenylmalononitrile

There total 2 articles about 2-fluoro-2-phenylmalononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

phenyl-malononitrile; sodium-compound (109707-86-0) → 2-fluoro-2-phenylmalononitrile (1961-36-0)

Guidance literature:

With 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; In tetrahydrofuran; at 0 - 20 ℃; for 0.2h;

DOI:10.1021/ja00179a047

Reference yield:

→ 2-fluoro-2-phenylmalononitrile (1961-36-0)

Guidance literature:

Phenylmalonitril, ClO3F/NaH;

Reference yield:

2-fluoro-2-phenylmalononitrile (1961-36-0) → cyano-fluorophenylacetamide (794586-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / Rhodococcus rhodochrous IFO 15564 cells / 504 h

2: 80 percent / methyl N-(triethylammonium-sulfonyl)carbamate / acetonitrile / 60 °C

With Burgess Reagent; Rhodococcus rhodochrous IFO 15564 cells; In acetonitrile;

DOI:10.1016/j.tetasy.2004.04.047

upstream raw materials:

phenyl-malononitrile; sodium-compound

Downstream raw materials:

1,1,3-Tricyano-2-amino-3-fluor-3-phenyl-propen-⁽¹⁾

cyano-fluorophenylacetamide

Refernces