2,4-Diamino-6-hydroxy-5-nitropyrimidine

Base Information

• Chemical Name: 2,4-Diamino-6-hydroxy-5-nitropyrimidine
• CAS No.: 3346-23-4
• Molecular Formula: C4H5 N5 O3
• Molecular Weight: 171.115
• Hs Code.: 2933599090
• Mol file: 3346-23-4.mol

Synonyms:4(1H)-Pyrimidinone,2,6-diamino-5-nitro- (9CI); 4(3H)-Pyrimidinone, 2,6-diamino-5-nitro- (8CI);4-Pyrimidinol, 2,6-diamino-5-nitro- (6CI,7CI);2,4-Diamino-6-hydroxy-5-nitropyrimidine; NSC 44924

Chemical Property of 2,4-Diamino-6-hydroxy-5-nitropyrimidine

Chemical Property:

• Vapor Pressure: 0.00272mmHg at 25°C
• Melting Point: >400°C
• Boiling Point: 285.9°Cat760mmHg
• Flash Point: 126.7°C
• PSA: 143.87000
• Density: 2.31g/cm³
• LogP: 0.94040
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Diamino-4-hydroxy-5-nitrosopyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Diamino-6-hydroxy-5-nitropyrimidine

There total 10 articles about 2,4-Diamino-6-hydroxy-5-nitropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.4%

2,6-diaminopyrimidin-4-ol (56-06-4) → 2,4-diamino-5-nitro-6-hydroxypyrimidine (3346-23-4)

Guidance literature:

With sulfuric acid; nitric acid; at 30 - 35 ℃; for 2h;

Reference yield:

thiophenol (108-98-5) + 2,4-diamino-6-benzyloxy-5-nitropyrimidine → Benzyl phenyl sulfide (831-91-4) + 2,4-diamino-5-nitro-6-hydroxypyrimidine (3346-23-4)

Guidance literature:

With triethylamine; In methanol; at 60 ℃; Rate constant;

DOI:10.1021/jm970363i

Reference yield:

thiophenol (108-98-5) + 2,4-diamino-5-nitro-6-(3-pyridylmethoxy)pyrimidine → 3-((phenylthio)methyl)pyridine (69966-47-8) + 2,4-diamino-5-nitro-6-hydroxypyrimidine (3346-23-4)

Guidance literature:

With triethylamine; In methanol; at 60 ℃; Rate constant;

DOI:10.1021/jm970363i

upstream raw materials:

thiophenol

2,6-diaminopyrimidin-4-ol

Downstream raw materials:

2,5,6-triamino-4-hydroxypyrimidine

Refernces

• 1、 -. "Method for preparing folic acid by virtue of micro-channel reaction (by machine translation)". Paragraph 0053-0056. . Retrieved 2020/12/14.