Pyridazine-4,5-diamine

Base Information

• Chemical Name: Pyridazine-4,5-diamine
• CAS No.: 28682-70-4
• Molecular Formula: C4H6N4
• Molecular Weight: 110.118
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90557538
• Wikidata: Q82439486
• Mol file: 28682-70-4.mol

Synonyms:Pyridazine-4,5-diamine;28682-70-4;4,5-DIAMINO-PYRIDAZINE;4,5-pyridazinediamine;4,5-Diaminopyridazine;4,5-PyridazinediaMine(9CI);SCHEMBL6278613;(5-amino-pyridazin-4-yl)-amine;DTXSID90557538;CYCNSKOONFXROI-UHFFFAOYSA-N;AMY24976;MFCD11110431;AKOS006307700;DS-6304;F10831;J-514069

Chemical Property of Pyridazine-4,5-diamine

Chemical Property:

• Boiling Point: 412.47 °C at 760 mmHg
• PKA: 8.20±0.10(Predicted)
• Flash Point: 232.469 °C
• PSA: 77.82000
• Density: 1.369 g/cm³
• LogP: 0.80340
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 110.059246208
• Heavy Atom Count: 8
• Complexity: 64.4

Purity/Quality:

99% ^*data from raw suppliers

4,5-Diaminopyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CN=N1)N)N
• Uses: 4,5-Diaminopyridazine is a reagent often aminated for its use in the synthesis of pharmaceuticals.

Technology Process of Pyridazine-4,5-diamine

There total 3 articles about Pyridazine-4,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

5-amino-4-nitropyridazine (118617-12-2) → pyridazine-4,5-diamine (28682-70-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 0.5h;

Reference yield:

4-amino-3,6-dichloro-5-nitropyridazine (28682-68-0) → pyridazine-4,5-diamine (28682-70-4)

Guidance literature:

4-amino-3,6-dichloro-5-nitropyridazine; With 5%-palladium/activated carbon; hydrogen; In methanol; at 25 ℃; under 2585.81 Torr;

With potassium carbonate; In methanol; dichloromethane; at 20 ℃;

Reference yield:

→ pyridazine-4,5-diamine (28682-70-4)

Guidance literature:

3,6-Dichloro-4-amino-5-nitropyridazin (VIII), H2 - Pd - C;

upstream raw materials:

5-amino-4-nitropyridazine

4-amino-3,6-dichloro-5-nitropyridazine

Downstream raw materials:

2-phenyl-1H-imidazo[4,5-d]pyridazine

Refernces

• 1、 Marcelis, Antonius T. M.,Tondijs, Hanna,Plas, Henk C. van der. "Amination of 4-Nitro- and 4-Cyanopyridazines by Liquid Ammonia/Potassium Permanganate". . p. 831 - 833. Retrieved 2007/10/02.