4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid

Base Information

• Chemical Name: 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid
• CAS No.: 1442439-46-4
• Molecular Formula: C₂₆H₂₂BrNO₄
• Molecular Weight: 492.369
• Mol file: 1442439-46-4.mol

Synonyms:4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid

Chemical Property of 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid

There total 14 articles about 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoate (1442439-45-3) → 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid (1442439-46-4)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃;

DOI:10.1016/j.ejmech.2013.02.012

Reference yield:

2,2-dimethylchroman (1198-96-5) → 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid (1442439-46-4)

Guidance literature:

Multi-step reaction with 10 steps

1: aluminum (III) chloride / dichloromethane / 0.5 h / 20 °C

2: sodium hypochlorite; sodium hydroxide / 1,4-dioxane / 96 h / 85 °C

3: sulfuric acid / ethanol / 95 °C

4: acetic acid; bromine / 20 °C

5: chromium(VI) oxide; acetic anhydride / acetic acid / 4 h / 0 °C

6: tetrahydrofuran; diethyl ether / -78 - 20 °C

7: pyridinium p-toluenesulfonate / methanol / 4 h / Reflux

8: sodium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 45 °C

9: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 30 h / Reflux

10: sodium hydroxide / ethanol / 20 °C

With chromium(VI) oxide; aluminum (III) chloride; sodium hypochlorite; sulfuric acid; water; bromine; pyridinium p-toluenesulfonate; acetic anhydride; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; acetic acid; ethyl acetate;

DOI:10.1016/j.ejmech.2013.02.012

Reference yield:

2,2-dimethyl-6-acetylchroman (32333-31-6) → 4-[[[8-bromo-2,2-dimethyl-4-(4-methylphenyl)-6-chromanyl]carbonyl]amino]benzoic acid (1442439-46-4)

Guidance literature:

Multi-step reaction with 9 steps

1: sodium hypochlorite; sodium hydroxide / 1,4-dioxane / 96 h / 85 °C

2: sulfuric acid / ethanol / 95 °C

3: acetic acid; bromine / 20 °C

4: chromium(VI) oxide; acetic anhydride / acetic acid / 4 h / 0 °C

5: tetrahydrofuran; diethyl ether / -78 - 20 °C

6: pyridinium p-toluenesulfonate / methanol / 4 h / Reflux

7: sodium hydroxide; water / tetrahydrofuran; ethanol / 2 h / 45 °C

8: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 30 h / Reflux

9: sodium hydroxide / ethanol / 20 °C

With chromium(VI) oxide; sodium hypochlorite; sulfuric acid; water; bromine; pyridinium p-toluenesulfonate; acetic anhydride; acetic acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; acetic acid; ethyl acetate;

DOI:10.1016/j.ejmech.2013.02.012

upstream raw materials:

4-(2-hydroxyphenyl)-2-methyl-2-butanol

2,2-dimethylchroman

2,2-dimethyl-6-acetylchroman

2,2-dimethylchroman-6-carboxylic acid

Refernces

• 1、 -. "METHOD OF MODULATING THE DEGREE OF ADIPOSE TISSUE DEPOSITED INTRAMUSCULARLY". Page/Page column. . Retrieved 2014/04/17.