6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde

Base Information

• Chemical Name: 6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde
• CAS No.: 1401165-57-8
• Molecular Formula: C₁₄H₈F₅NOS
• Molecular Weight: 333.282
• Mol file: 1401165-57-8.mol

Synonyms:6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde

Chemical Property of 6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde

Chemical Property:

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Technology Process of 6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde

There total 1 articles about 6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

pentafluoro(4-iodophenyl)-λ6-sulfane (286947-68-0) + 6-ethynylpyridine-2-carboxaldehyde (183438-97-3) → 6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde (1401165-57-8)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In acetonitrile; at 20 - 80 ℃; for 0.5h;

Reference yield: 47.0%

(R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) + 6-((4-(pentafluorothio)phenyl)ethynyl)picolinaldehyde (1401165-57-8) → (2R)-3-methyl-2-{[(6-{[4-(pentafluoro-λ6-sulfanyl)phenyl]ethynyl}pyridin-2-yl)methyl]amino}butan-1-ol

Guidance literature:

With acetic acid; MP-cyanoborohydride; In methanol; dichloromethane; at 20 ℃;

upstream raw materials:

pentafluoro(4-iodophenyl)-λ⁶-sulfane

6-ethynylpyridine-2-carboxaldehyde

Refernces