Technology Process of C14H9BrN2O
There total 9 articles about C14H9BrN2O which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
1,4-dioxane;
at 100 ℃;
for 2h;
Inert atmosphere;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere
1.2: 2 h / -78 - 20 °C
2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere
3.1: tetrahydrofuran / 1 h / -78 - 20 °C
4.1: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 2.25 h / -20 - 20 °C / Inert atmosphere
6.1: sodium hydroxide / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Sealed tube
With
n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrahydrofuran / 1 h / -78 - 20 °C
2: trifluoroacetic acid / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
3: triethylamine / dichloromethane / 2.25 h / -20 - 20 °C / Inert atmosphere
4: sodium hydroxide / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere; Sealed tube
With
triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
