5-methyl-D-tryptophan

Base Information

• Chemical Name: 5-methyl-D-tryptophan
• CAS No.: 99295-79-1
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.255
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40357429
• Nikkaji Number: J232.213G
• Wikidata: Q27123484
• Metabolomics Workbench ID: 58287
• Mol file: 99295-79-1.mol

Synonyms:5-methyl-D-tryptophan;99295-79-1;(R)-2-Amino-3-(5-methyl-1H-indol-3-yl)propanoic acid;(2R)-2-amino-3-(5-methyl-1H-indol-3-yl)propanoic acid;MFCD01677297;SCHEMBL7614399;CHEBI:52525;DTXSID40357429;MFCD09841957;AKOS025287279;CS-W000583;AS-41984;5-Methyl-D-tryptophan (H-D-Trp(5-Me)-OH);A858483;Q27123484;(R)-2-Amino-3-(5-methyl-1H-indol-3-yl)propanoicacid

Chemical Property of 5-methyl-D-tryptophan

Chemical Property:

• Boiling Point: 455.1 °C at 760 mmHg
• Flash Point: 229.1 °C
• PSA: 79.11000
• Density: 1.313 g/cm³
• LogP: 2.13100
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 218.105527694
• Heavy Atom Count: 16
• Complexity: 270

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-Amino-3-(5-methyl-1H-indol-3-yl)propanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)NC=C2CC(C(=O)O)N
• Isomeric SMILES: CC1=CC2=C(C=C1)NC=C2C[C@H](C(=O)O)N

Technology Process of 5-methyl-D-tryptophan

There total 15 articles about 5-methyl-D-tryptophan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-methyl-L-tryptophan methyl ester (93299-41-3) → 2-Amino-3-(5-methyl-1H-indol-3-yl)-propionic acid (154-06-3,951-55-3,2283-43-4,99295-79-1,142436-29-1)

Guidance literature:

With sodium hydroxide; In methanol;

Reference yield: 60.0%

5-methyl-Nb-benzyloxycarbonyl-L-tryptophan (93272-14-1) → 2-Amino-3-(5-methyl-1H-indol-3-yl)-propionic acid (154-06-3,951-55-3,2283-43-4,99295-79-1,142436-29-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; for 5h; Ambient temperature;

Reference yield:

5-methyl-DL-tryptophan (951-55-3) → 2-Amino-3-(5-methyl-1H-indol-3-yl)-propionic acid (154-06-3,951-55-3,2283-43-4,99295-79-1,142436-29-1)

Guidance literature:

With dibromide radical anion; In water; at 20 ℃; Rate constant; pH 2.5 to 13.5;

DOI:10.1021/j100195a029

upstream raw materials:

5-methyl-DL-tryptophan

5-methyl-N_b-benzyloxycarbonyl-L-tryptophan

5-methyl-L-tryptophan methyl ester

(S)-dimethyl pyrrolidine-1,2-dicarboxylate

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS". Page/Page column 45-49; 61. . Retrieved 2010/12/31.
• 2、 Irie, Kunihiko,Ishida, Akihiko,Nakamura, Tohru,Oh-ishi, Tokuro. "Syntheses of Substituted L- and D-Tryptophans". . p. 2126 - 2139. Retrieved 2007/10/02.