2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO-

Base Information

• Chemical Name: 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO-
• CAS No.: 99199-54-9
• Molecular Formula: C₁₀H₉BrO₃
• Molecular Weight: 257.084
• Mol file: 99199-54-9.mol

Synonyms:6-BROMOCHROMANE-2-CARBOXYLIC ACID;2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO-

Chemical Property of 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO-

Chemical Property:

• PSA: 46.53000
• LogP: 2.22730

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromochromane-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO-

There total 15 articles about 2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 6-BROMO-3,4-DIHYDRO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl (R)-6-bromochroman-2-carboxylate → (R)-6-bromochroman-2-carboxylic acid (474111-15-4,99199-54-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.tetasy.2015.07.006

Reference yield: 92.0%

→ (R)-6-bromochroman-2-carboxylic acid (474111-15-4,99199-54-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

Reference yield: 85.0%

6-bromo-3,4-dihydro-2H-chroman-2-carboxylic acid ethyl ester → 6-bromo-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid (99199-54-9)

Guidance literature:

With sodium hydroxide; In water; at 25 - 30 ℃; for 1h;

DOI:10.1002/jhet.360

upstream raw materials:

6-bromochroman-2-carboxylic acid methyl ester

o-hydroxyacetophenone

ethyl 4-oxo-4H-1-benzopyran-2-carboxylate

ethyl Chroman-2-carboxylate

Refernces

• 1、 -. "CHROMANE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS". Page/Page column 77. . Retrieved 2019/04/27.
• 2、 Kim, Dong Woon,Maqusood Alam,Lee, Young Hun,Khan, M. Naseer A.,Zhang, Yong,Lee, Yong Sup. "An efficient and practical enantiospecific synthesis of methyl chromanone- and chroman-2-carboxylates". . p. 912 - 917. Retrieved 2015/08/24.