5-BROMO-2-CHLORO-3-DIMETHOXYMETHYL-PYRIDINE

Base Information

• Chemical Name: 5-BROMO-2-CHLORO-3-DIMETHOXYMETHYL-PYRIDINE
• CAS No.: 928653-74-1
• Molecular Formula: C₈H₉BrClNO₂
• Molecular Weight: 266.522
• Hs Code.: 2933399090
• Mol file: 928653-74-1.mol

Synonyms:5-Bromo-2-chloro-3-dimethoxymethyl-pyridine;

Chemical Property of 5-BROMO-2-CHLORO-3-DIMETHOXYMETHYL-PYRIDINE

Chemical Property:

• Vapor Pressure: 0.00799mmHg at 25°C
• Refractive Index: 1.541
• Boiling Point: 276.6°Cat760mmHg
• Flash Point: 121.1°C
• PSA: 31.35000
• Density: 1.535g/cm³
• LogP: 2.78890

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-chloro-3-dimethoxymethyl-pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-CHLORO-3-DIMETHOXYMETHYL-PYRIDINE

There total 3 articles about 5-BROMO-2-CHLORO-3-DIMETHOXYMETHYL-PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-bromo-2-chloropyridine-3-carbaldehyde (228251-24-9) + trimethyl orthoformate (149-73-5) → 5-bromo-2-chloro-3-(dimethoxymethyl)pyridine (928653-74-1)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 2h; Reflux;

Reference yield:

5-bromo-2-chloronicotinic acid (29241-65-4) → 5-bromo-2-chloro-3-(dimethoxymethyl)pyridine (928653-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 2 h / 80 °C

1.2: 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / -10 - 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / methanol / 2 h / Reflux

With lithium aluminium tetrahydride; thionyl chloride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

Reference yield:

5-bromo-2-chloro-N-methoxy-N-methylnicotinamide (885223-63-2) → 5-bromo-2-chloro-3-(dimethoxymethyl)pyridine (928653-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / -10 - 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 2 h / Reflux

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;

upstream raw materials:

5-bromo-2-chloronicotinic acid

5-bromo-2-chloro-N-methoxy-N-methylnicotinamide

5-bromo-2-chloropyridine-3-carbaldehyde

trimethyl orthoformate

Refernces