3-BROMO-4-TRIFLUOROMETHYLNITROBENZENE

Base Information

• Chemical Name: 3-BROMO-4-TRIFLUOROMETHYLNITROBENZENE
• CAS No.: 875238-74-7
• Molecular Formula: C₇H₃BrF₃NO₂
• Molecular Weight: 270.006
• Mol file: 875238-74-7.mol

Synonyms:2-bromo-4-nitro-1-(trifluoromethyl)benzene

Chemical Property of 3-BROMO-4-TRIFLUOROMETHYLNITROBENZENE

Chemical Property:

• Boiling Point: 258℃
• Flash Point: 110℃
• Density: 1.788
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% purity ^*data from raw suppliers

2-Bromo-4-nitro-1-(trifluoromethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-BROMO-4-TRIFLUOROMETHYLNITROBENZENE

There total 1 articles about 3-BROMO-4-TRIFLUOROMETHYLNITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-bromo-4-nitrobenzoic acid (16426-64-5) → 2-bromo-4-nitro-1-(trifluoromethyl)benzene (875238-74-7)

Guidance literature:

With sulfur tetrafluoride; hydrogen fluoride; at 85 ℃; for 24h; Autoclave; Inert atmosphere;

DOI:10.1021/acs.joc.9b03011

Reference yield: 77.0%

2-bromo-4-nitro-1-(trifluoromethyl)benzene (875238-74-7) → 3-bromo-4-(trifluoromethyl)aniline (172215-91-7)

Guidance literature:

With hydrogenchloride; iron; ammonium chloride; In water; isopropyl alcohol; Reflux;

DOI:10.1021/acs.joc.9b03011

Reference yield:

thiomorpholine 1,1-dioxide (39093-93-1) + 2-bromo-4-nitro-1-(trifluoromethyl)benzene (875238-74-7) → 4-(5-nitro-2-(trifluoromethyl)phenyl)thiomorpholine-1,1-dioxide

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

upstream raw materials:

2-bromo-4-nitrobenzoic acid

Downstream raw materials:

1-(4-nitro-2-trifluoromethylphenyl)piperidin-2-one

3-bromo-4-(trifluoromethyl)aniline

Refernces