N-Phenyl-2,5-dimethylpyrrolidine

Base Information

• Chemical Name: N-Phenyl-2,5-dimethylpyrrolidine
• CAS No.: 37035-03-3
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.274
• Mol file: 37035-03-3.mol

Synonyms:N-Phenyl-2,5-dimethylpyrrolidine

Chemical Property of N-Phenyl-2,5-dimethylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Phenyl-2,5-dimethylpyrrolidine

There total 10 articles about N-Phenyl-2,5-dimethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

hydrogen (1333-74-0) + 2,5-hexanedione (110-13-4) + nitrobenzene (98-95-3,26969-40-4) → 2,5-dimethyl-1-phenyl-1H-pyrrole (83-24-9) + N-Phenyl-2,5-dimethylpyrrolidine (37035-03-3) + aniline (62-53-3)

Guidance literature:

With potassium tetrachloroplatinate(II); bis(3-sulfonatophenyl)(4-tert-butylphenyl)phosphane disodium salt; In diethyl ether; n-heptane; water; at 20 ℃; for 18h; Temperature;

DOI:10.1039/c5dt01825k

Reference yield: 55.0%

2,5-hexanedione (110-13-4) + aniline (62-53-3) → 2,5-dimethyl-1-phenyl-1H-pyrrole (83-24-9) + N-Phenyl-2,5-dimethylpyrrolidine (37035-03-3)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; Yields of byproduct given; electrolysis;

Reference yield:

2,5-hexanedione (110-13-4) + aniline (62-53-3) → 1-phenyl-2,5-cis-dimethylpyrrolidine (81480-60-6) + 1-phenyl-2,5-trans-dimethylpyrrolidine (37035-03-3,81480-60-6,81480-61-7)

Guidance literature:

With potassium hydroxide; sodium cyanoborohydride; acetic acid; In methanol; at -10 - 20 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)85010-9

upstream raw materials:

2,5-dimethyltetrahydrofuran

hexane-2,5-diol

aniline

2,5-hexanedione

Downstream raw materials:

2,5-dimethyl-1-phenyl-1H-pyrrole

Refernces

• 1、 Menuel,Bertaut,Monflier,Hapiot. "Cyclodextrin-based PNN supramolecular assemblies: a new class of pincer-type ligands for aqueous organometallic catalysis". . p. 13504 - 13512. Retrieved 2015/08/03.
• 2、 Boga,Manescalchi,Savoia. "Diastereoselective synthesis of 2,5-dimethylpyrrolidines and 2,6- dimethylpiperidines by reductive amination of 2,5-hexanedione and 2,6- heptanedione with hydride reagents". . p. 4709 - 4722. Retrieved 2007/10/02.