2-Pyridinecarboxamide,3-amino-N-hydroxy-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxamide,3-amino-N-hydroxy-(9CI)
• CAS No.: 98140-94-4
• Molecular Formula: C6H7 N3 O2
• Molecular Weight: 153.14
• Hs Code.: 2933399090
• Mol file: 98140-94-4.mol

Synonyms:Picolinohydroxamicacid, 3-amino- (6CI)

Chemical Property of 2-Pyridinecarboxamide,3-amino-N-hydroxy-(9CI)

Chemical Property:

• PSA: 91.73000
• LogP: 0.93880

Purity/Quality:

99%min ^*data from raw suppliers

3-Amino-n-hydroxy-2-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxamide,3-amino-N-hydroxy-(9CI)

There total 2 articles about 2-Pyridinecarboxamide,3-amino-N-hydroxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 3-aminopyridine-2-carboxylate (27507-15-9) → 3-amino-2-picolinehydroxamic acid (98140-94-4)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In methanol; water; for 48h;

DOI:10.1021/jo030017a

Reference yield:

3-amino-pyridine-2-carboxylic acid (1462-86-8) → 3-amino-2-picolinehydroxamic acid (98140-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / H₂SO₄ / 48 h / Heating

2: 90 percent / hydroxylamine hydrochloride; sodium hydroxide / H₂O; methanol / 48 h

With sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; In methanol; water;

DOI:10.1021/jo030017a

Reference yield: 32.0%

3-amino-2-picolinehydroxamic acid (98140-94-4) → 3-hydroxypyridine-2-carboxylic acid (874-24-8) + 3-hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazine (655244-89-6)

Guidance literature:

With hydrogenchloride; sodium nitrite; In water; at 5 ℃; for 0.5h;

DOI:10.1021/jo030017a

upstream raw materials:

ethyl 3-aminopyridine-2-carboxylate

3-amino-pyridine-2-carboxylic acid

Downstream raw materials:

3-hydroxypyridine-2-carboxylic acid

3-hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazine

2-benzyloxycarbonylamino-2-methyl-propionic acid 4-oxo-4H-pyrido[3,2-d]pyrimidin-3-yl ester

2-benzyloxycarbonylamino-2-methyl-propionic acid 4-oxo-4H-pyrido[3,2-d][1,2,3]triazin-3-yl ester

Refernces