diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate

Base Information

• Chemical Name: diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate
• CAS No.: 69872-14-6
• Molecular Formula: C₁₂H₁₃BrN₂O₆
• Molecular Weight: 361.149
• Mol file: 69872-14-6.mol

Synonyms:diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate

Chemical Property of diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate

There total 1 articles about diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3-nitropyridine (5435-54-1) → diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate (69872-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: bromine / water / 2 h / 50 °C

2.1: diethylamine; trichlorophosphate / 5 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0 °C

3.2: 1 h / 0 °C

With bromine; sodium hydride; diethylamine; trichlorophosphate; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2011.11.070

Reference yield:

diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate (69872-14-6) → 3-bromo-4-methyl-5-nitropyridine (69872-15-7)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 15h;

Reference yield:

diethyl 2-(3-bromo-5-nitro-4-pyridyl)propanedioate (69872-14-6) → 4-bromo-1H-pyrrolo[2,3-c]pyridine (69872-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; water / 16 h / Reflux

2: N,N-dimethyl-formamide / 4 h / 90 °C

3: iron; acetic acid / 3 h / 90 °C

With hydrogenchloride; water; iron; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2011.11.070

upstream raw materials:

4-hydroxy-3-nitropyridine

Downstream raw materials:

3-bromo-4-methyl-5-nitropyridine

tert-butyl 4-bromo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate

4-bromo-1H-pyrrolo[2,3-c]pyridine

Refernces