cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine

Base Information

• Chemical Name: cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine
• CAS No.: 78961-35-0
• Molecular Formula: C₁₄H₁₅NO₂
• Molecular Weight: 229.279
• Mol file: 78961-35-0.mol

Synonyms:cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine

Chemical Property of cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine

There total 2 articles about cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.1%

3-Quinuclidinone (3731-38-2) + salicylaldehyde (90-02-8) → cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine (78961-35-0)

Guidance literature:

With sodium hydroxide; In methanol; for 34h; Heating;

DOI:10.1007/BF00505697

Reference yield:

2-methyl-benzyl alcohol (89-95-2) + 3-quinuclidinone hydrochloride (1193-65-3) → cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine (78961-35-0)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1007/BF02464105

Reference yield: 87.0%

acetic anhydride (108-24-7) + cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine (78961-35-0) → Z-2-(2'-acetoxyphenyl)methylene-3-quinuclidone (410083-78-2)

Guidance literature:

at 100 ℃; for 8h;

DOI:10.1023/A:1011664807422

upstream raw materials:

3-Quinuclidinone

salicylaldehyde

2-methyl-benzyl alcohol

3-quinuclidinone hydrochloride

Downstream raw materials:

cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine Oxime

cis-2-(2'-Hydroxybenzylidene)-3-oxoquinuclidine Oxime

2-(2-hydroxyphenylmethyl)-3-quinuclidone

Z-2-(2'-acetoxyphenyl)methylene-3-quinuclidone

Refernces

• 1、 Filipenko, T. Ya.,Gorbyleva, O. I.,Turchin, K. F.,Anisimova, O. S.,Peresleni, E. M.,et al.. "SYNTHESIS AND THREE-DIMENSIONAL STRUCTURE OF 2-ARYLIDENE-3-OXOQUINUCLIDINE OXIMES". . p. 490 - 497. Retrieved 2007/10/02.