Dabsyl-L-methionine

Base Information

• Chemical Name: Dabsyl-L-methionine
• CAS No.: 97684-99-6
• Molecular Formula: C19H24 N4 O4 S2
• Molecular Weight: 436.556
• ChEMBL ID: CHEMBL3526650
• DSSTox Substance ID: DTXSID50555050
• Nikkaji Number: J208.358B
• Mol file: 97684-99-6.mol

Synonyms:Dabsyl-L-methionine;97684-99-6;(2S)-2-[[4-[[4-(dimethylamino)phenyl]diazenyl]phenyl]sulfonylamino]-4-methylsulfanylbutanoic acid;Dabsyl-L-methionine ,;dabsyl-methionine;Dbs-Met-OH;CHEMBL3526650;DTXSID50555050;XDA68499;MFCD00059323;Dabsyl-L-methionine (Dbs-L-Met-OH);HY-W141864;CS-0201660;D1457;D89861;4-Dimethylaminoazobenzene-4'-sulfonyl-L-methionine;N-(4-{(E)-[4-(Dimethylamino)phenyl]diazenyl}benzene-1-sulfonyl)-L-methionine;(2S)-2-{[(4-{(E)-[4-(Dimethylamino)phenyl]diazenyl}phenyl)sulfonyl]amino}-4-(methylsulfanyl)butanoic acid, AldrichCPR;(S,E)-2-(4-((4-(dimethylamino)phenyl)diazenyl)phenylsulfonamido)-4-(methylthio)butanoic acid

Chemical Property of Dabsyl-L-methionine

Chemical Property:

• Refractive Index: 1.619
• PSA: 145.11000
• LogP: 5.12430
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 436.12389761
• Heavy Atom Count: 29
• Complexity: 635

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dabsyl-L-methionine >95.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)S(=O)(=O)NC(CCSC)C(=O)O
• Isomeric SMILES: CN(C)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)S(=O)(=O)N[C@@H](CCSC)C(=O)O

Technology Process of Dabsyl-L-methionine

There total 2 articles about Dabsyl-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) + dabsyl chloride (56512-49-3) → Dabsyl-L-Methionine (97684-99-6)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃;

DOI:10.3390/molecules25092250

Reference yield:

C19H24N4O5S2 (1231713-54-4) → Dabsyl-L-Methionine (97684-99-6)

Guidance literature:

With DL-dithiothreitol; at 37 ℃; pH=7.4; aq. buffer;

DOI:10.1124/dmd.110.037663

upstream raw materials:

C₁₉H₂₄N₄O₅S₂

L-methionine

dabsyl chloride

Refernces

• 1、 Brunell, David,Sagher, Daphna,Kesaraju, Shailaja,Brot, Nathan,Weissbach, Herbert. "Studies on the metabolism and biological activity of the epimers of sulindac". experimental part. p. 1014 - 1021. Retrieved 2012/03/10.