Cyclohexaneacetic acid,a-[[(phenylmethoxy)carbonyl]amino]-

Base Information

• Chemical Name: Cyclohexaneacetic acid,a-[[(phenylmethoxy)carbonyl]amino]-
• CAS No.: 93025-71-9
• Molecular Formula: C16H21 N O4
• Molecular Weight: 0
• Hs Code.: 2924299090
• Mol file: 93025-71-9.mol

Synonyms:Cyclohexaneaceticacid, a-(carboxyamino)-, N-benzyl ester(7CI)

Chemical Property of Cyclohexaneacetic acid,a-[[(phenylmethoxy)carbonyl]amino]-

Chemical Property:

• Vapor Pressure: 1.68E-10mmHg at 25°C
• Refractive Index: 1.552
• Boiling Point: 492.1°C at 760 mmHg
• Flash Point: 251.4°C
• PSA: 75.63000
• Density: 1.2g/cm³
• LogP: 3.33720

Purity/Quality:

98%min ^*data from raw suppliers

2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(((Benzyloxy)carbonyl)amino)-2-cyclohexylacetic Acid can be synthesized from 2-Amino-2-cyclohexylacetic Acid (5664-29-9), an important building block.

Technology Process of Cyclohexaneacetic acid,a-[[(phenylmethoxy)carbonyl]amino]-

There total 3 articles about Cyclohexaneacetic acid,a-[[(phenylmethoxy)carbonyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(1-cyclohexyl-2-nitro-ethyl)-carbamic acid benzyl ester (232598-64-0) → N-(benzyloxycarbonyl)cyclohexylglycine (93025-71-9)

Guidance literature:

With potassium permanganate; In tetrahydrofuran; pH=11;

DOI:10.1016/S0040-4039(99)00770-4

Reference yield:

2-cyclohexylglycine (5664-29-9) + benzyl chloroformate (501-53-1,94274-21-2) → N-(benzyloxycarbonyl)cyclohexylglycine (93025-71-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1039/jr9620001440

Reference yield:

benzyl (cyclohexyl(phenylsulfonyl)methyl)carbamate (232598-56-0) → N-(benzyloxycarbonyl)cyclohexylglycine (93025-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaH / tetrahydrofuran / 1 h / 20 °C

2: 88 percent / KMnO₄ / tetrahydrofuran / pH 11

With potassium permanganate; sodium hydride; In tetrahydrofuran; 1: Substitution / 2: Oxidation;

DOI:10.1016/S0040-4039(99)00770-4

upstream raw materials:

2-cyclohexylglycine

benzyl chloroformate

(1-cyclohexyl-2-nitro-ethyl)-carbamic acid benzyl ester

benzyl (cyclohexyl(phenylsulfonyl)methyl)carbamate

Downstream raw materials:

Benzyloxycarbonylamino-cyclohexyl-acetic acid methyl ester

Refernces

• 1、 Ballini, Roberto,Petrini, Marino. "Base assisted substitution of α-amidoalkyl sulfones by nitromethane anion. A new entry to functionalized α-amino acids". . p. 4449 - 4452. Retrieved 2007/10/03.