ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate

Base Information

• Chemical Name: ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate
• CAS No.: 174320-08-2
• Molecular Formula: C₂₂H₄₀N₄O₃
• Molecular Weight: 408.585
• Mol file: 174320-08-2.mol

Synonyms:ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate

Chemical Property of ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate

There total 8 articles about ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triaza-2-hexadecenoate → ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate (174320-08-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; chloroform; at 25 ℃; for 12h;

DOI:10.1246/bcsj.71.1221

Reference yield:

Spermine (71-44-3) + ethyl 3-(4-methoxyphenyl)propynoate (51718-85-5) → ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate (174320-08-2)

Guidance literature:

With chloroform; hydrogen; platinum(IV) oxide; Yield given. Multistep reaction;

DOI:10.1021/ja953541a

Reference yield:

ethyl 3-(4-methoxyphenyl)propynoate (51718-85-5) → ethyl 16-amino-3-(4-methoxyphenyl)-4,8,13-triazahexadecanoate (174320-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / ethanol / 2 h / Heating

2: 81 percent / H₂ / platinum(IV) oxide / CHCl₃; ethanol / 12 h / 25 °C

With hydrogen; platinum(IV) oxide; In ethanol; chloroform; 1: Michael addition / 2: Catalytic hydrogenation;

DOI:10.1246/bcsj.71.1221

upstream raw materials:

Spermine

ethyl 3-(4-methoxyphenyl)propynoate

ethyl 4-methoxybenzoylacetate

para-iodoanisole

Downstream raw materials:

(+/-)-8-(4-methoxyphenyl)-1,5,9,13-tetraazacycloheptadecan-6-one

Refernces

• 1、 Kuroki, Yoshichika,Ishihara, Kazuaki,Hanaki, Naoyuki,Ohara, Suguru,Yamamoto, Hisashi. "Metal-Templated Macrolactamization of Triamino and Tetramino Esters. Facile Synthesis of Macrocyclic Spermidine and Spermine Alkaloids, (S)-(+)-Dihydroperiphylline, (±)-Buchnerine, (±)-Verbacine, (±)-Verbaskine, and (±)-Verbascenine". . p. 1221 - 1230. Retrieved 2007/10/03.