N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride

Base Information

• Chemical Name: N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride
• CAS No.: 103377-40-8
• Molecular Formula: C₁₅H₂₀ClNO₃
• Molecular Weight: 297.782
• Mol file: 103377-40-8.mol

Synonyms:N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride

Chemical Property of N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride

There total 2 articles about N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine (82717-96-2,122076-80-6) → N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride (103377-40-8)

Guidance literature:

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine; With hydrogenchloride; In 1,4-dioxane; dichloromethane; at -5 - 0 ℃;

With oxalyl dichloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; at -5 - 0 ℃; Further stages.;

DOI:10.1021/ol020136x

Reference yield:

→ N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride (103377-40-8)

Guidance literature:

Reference yield:

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine acid chloride (103377-40-8) → enalapril (75847-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide; CH₂Cl₂; dioxane / 1 h / 20 °C

2: DBU / acetonitrile; CH₂Cl₂ / 8 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ol020136x

upstream raw materials:

[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

Downstream raw materials:

C₁₈H₂₆N₂O₄

Amprace

enalapril

Refernces

• 1、 -. "Process for preparing an angiotensin converting enzyme inhibitor". . . Retrieved 2008/06/13.